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Held immediately prior to the 3rd Annual Biodefense August 18-19, 2004


Tuesday, August 17

8:00 Poster & Exhibit Viewing, Coffee

Rare Transcript and Single Cell Analysis:
Applications in Systems Biology


8:30 Chairperson's Remarks

8:35 Nanosystems Biology
Dr. James R. Heath, Elizabeth W. Gilloon Professor of Chemistry, California Institute of Technology

9:05 Higher Resolution Genomic Analysis With Microarrays
Dr. Yanxiang Cao, Program Manager, Expression Research, Affymetrix, Inc.
Gene expression analysis with microarrays allows massively parallel measurement of thousands of genes at genome scale. However, these studies may suffer from relatively low resolution in the following two aspects: 1. they are often limited at the gene level due to 3' bias in sample preparation assays, 2. they often require the use of heterogeneous biological samples in order to obtain at least the minimal quantity of targets required to meet detection sensitivity. It has become very evident that using cell-type specific samples and even single cells is necessary to de-convolute the complex biological systems to address specific problems. Gene expression analysis beyond the gene level and beyond 3' sequences will provide a wealth of information on molecular events which have significant impact on gene function, such as alternative splicing. Assays enabling gene expression analysis from fewer homogeneous cells and single cells, and assays enabling full-length representation of transcripts in the hybridization targets for transcript and exon-level expression analysis are being developed.

9:35 Single Molecule Amplification in a Continuous Flow LabChip Device
Dr. Mark T. Roskey, Vice President, Worldwide Marketing, Caliper Life Sciences, Inc. 
We have developed an integrated system to automate high throughput, continuous flow PCR in a microfludic chip. This in-line LabChip amplification system integrates reaction assembly, thermal cycling, and fluorescent detection all in a single device at nanoliter volume scale. The systems unique configuration and continuous flow analysis capabilities enable detection and genotyping of rare nucleic acid molecules.

10:05 Poster & Exhibit Viewing, Coffee Break

10:30 Single Molecule Detection and Manipulation
Dr. Andrew Berlin, Principal Engineer, Microsystems & MEMS Technology, Intel Corp. 
Applications ranging from whole-genome DNA sequencing to early disease detection can benefit greatly from improved sensitivity of molecular detection technologies. This talk will describe a set of microfluidic techniques for isolating and dispensing single molecules of DNA. We will also describe an optical approach to detection and identification of molecules in solution, based on Surface-Enhanced Raman Spectroscopy (SERS), that achieves single molecule levels of sensitivity on a variety of analytes. 

11:00 Microdevices for Biomolecular Detection
Dr. Scott Manalis, Associate Professor, Biological Engineering, Massachusetts Institute of Technology 
Our research focuses on using silicon microfabrication to develop quantitative, high throughput and real-time techniques for measuring biomolecular interactions. In this talk we will present: i) an entirely new detection method where specific biomolecules adsorb to the walls of a suspended microchannel resonator and thereby lower its resonant frequency, ii) the real-time detection of DNA using silicon field-effect sensors, and iii) the integration of mechanical and electrical detectors with microfluidics.

11:30 Micro/Nano Technologies for Single-Molecule Detection
Dr. Jeff T.-H. Wang, Ph.D. Assistant Professor, Mechanical Engineering Department & Whitaker Biomedical Engineering Institute, Johns Hopkins University 
A highly sensitive, specific, and rapid biological detection platform is sought-after in many areas such as disease diagnostics, study of genomics and proteomics, and detection of bioterrorist agents. We have shown that biosensing with single-molecule sensitivity is achieved by using confocal optics and fluorescent nanoparticulates. Performing single-molecule detection on a microfluidic chip, where transport of biomolecules is effectively controlled, enables precise and high-through analysis of low-abundance species. 

12:00 Panel Discussion with the Speakers

12:30 Lunch on your own

Minimally Invasive Medical Technology

2:00 Chairperson's Remarks
Dr. Shuvo Roy, Co-Director, BioMEMS Laboratory, Department of Biomedical Engineering, The Cleveland Clinic Foundation

2:05 High Resolution Micromachined Ultrasonic Transducers for Minimally Invasive Imaging
Dr. Aaron Fleischmann, Co-Director, BioMEMS Laboratory, Department of Biomedical Engineering, The Cleveland Clinic Foundation 
Minimally invasive procedures typically result in better patient outcomes with reduced pain, shorter hospital stays and less scarring. However, the surgeon no longer has the sense of touch and feel that is associated with traditional open procedures, which allows them to feel below the surface of the tissue. The sense of touch allows for the determination of pulse and the hardness of tissue and tells the surgeon where to proceed. The talk will present recent work on micromachined high resolution ultrasonic transducers, suitable for minimally invasive surgery that will allow the surgeon to image below the surface of the tissue.

2:35 Intravascular Drug Delivery Microsystems
Dr. Michael Reed, Professor of Electrical Engineering and Biomedical Engineering, Department of Electrical and Computer Engineering, University of Virginia 
The current generation of drug delivery stents employ polymeric coatings to deliver antirestenotic therapies. We have developed alternative technologies to deliver drugs and genes into the vascular wall using devices with nanoporous metallic coatings and deployable microneedles. The clinical advantages of these features will be presented, along with drug elution profiles and results of in vivo tests of these technologies.

3:05 Catheter Microsensors
Dr. William Suh, Senior Scientist, Verimetra, Inc. 
Micro sensors at the distal end of catheters help surgeons improve vascular intervention procedures because they allow surgeons to make intra-operative decisions. They are embedded directly onto the selected surfaces of catheters by multiple depositions of thin films. A few examples of catheter sensors will be discussed.

3:35 Creating Integrated Surgical Tools Using MEMS-based Sensors
Dr. Amit Lal, Assistant Professor, Electrical & Computer Engineering Department, Cornell University

4:05 Panel Discussion

4:30 Close of Conference


Call for Sponsors and Exhibitors
Showcase your company's expertise, brand your solutions and develop revenue opportunities with qualified decision-makers by becoming an Exhibitor or Sponsor of BioMEMS and NANOtech World 2004! Contract exhibit booth space by June 15, 2004 and you will save $300! If you want to discuss sponsoring or exhibiting at BioMEMS and NANOtech 2004, please contact Angela Parsons at 781-972-5467 or


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