Structure-Based Drug Design (SBD) has been in use within the pharmaceutical industry for over twenty-five years. Given the multi-disciplinary nature of drug discovery and development, SBD can hardly be the unique success factor. However, SBD is playing an increasingly important role. SBD of compound properties are still developing and growing in acceptance. In this program, we wish to highlight some recent breakthroughs and successes using SBD, including the accompanying interest in ligand-based. We especially seek presentations of recent breakthroughs or “unpublished work” in the following areas:
- Discoveries “leading to development candidates” that can be shown
- The “Med Chem” perspective- property optimization in parallel to SBD
- Considerations of physicochemical compound properties
- Considerations of in vitro versus in vivo pharmacological compound properties
- The computational or structural viewpoint
- Computational or structural methodology
- Ligand-Based Design
- The diverse roles of water in ligand binding to targets
- Ligand design including solvents
- Biophysical approaches
- MS
- SPR
- X-ray Crystallography
- NMR
- Homology Models
- Virtual Screening
- QSAR
- Combination of the above
- How to cope with structural flexibility of the target
- How to cope with selectivity issues (e.g. kinases, GPCR's ...)
- Novel targets and the validations of the targets
2009 Program Suggestions:
For those of you not yet sure of your topic for submission, please mark your calendar and share some suggestions with us so we can improve this year’s program. Please email me key topic and speaker suggestions for the 2009 program at mlieberman@pharmaseries.com -- Key Topics and Speakers: What for you are the key topics and areas of interest upon which we should focus (top 6-8) in 2009? Why? If you attended in 2008, are there some issues we covered in 2008 on which we should spend less time or some on which we should spend more time? Who would you like to see address the issues you mentioned?
2009 Speaking Proposal:
To be considered for an oral presentation, please submit your title and a 3-4 sentence summary on your ‘Success Story’ or ‘Case Presentation’ for review by our Scientific Advisory Committee.
Please click here to submit your speaking proposal.
For questions or suggestions about the meeting, please contact:
Micah Lieberman, Conference Producer
Phone: 541-482-4709
E-mail: mlieberman@pharmaseries.com
For exhibit, partnering and sponsorship information, please contact:
Katelin Fitzgerald, Manager Business Development
Phone: 781-972-5458
Email: kfitzgerald@healthtech.com