2015 BPD Header

Cambridge Healthtech Institute’s 7th Annual
Optimizing Cell Line Development
Enhancing Expression
August 6-7, 2015
Part of CHI's 7th Annual The Bioprocessing Summit

August 3-7, 2015 | Westin Copley Place Hotel | Boston, Massachusetts


Preliminary Agenda 

The “Optimizing Cell Line Development” meeting features experts sharing their case studies and anecdotes that illustrate the strategies they use to reach enhanced expression and lower costs. Their research and experiences provide meaningful insights into how to best select cell lines and hosts, and develop high-producers into late-stage production. Gaining a greater understanding of cells through sequencing and the omics sciences will also be addressed, including the CHO genome research, metabolomics, assays, and QPCR. In addition, challenges for introducing new technologies will be discussed, along with an overview of industrial trends and regulatory perspectives.


OPTIMIZING PROCESS DEVELOPMENT

Upstream Process Optimization, Automation and Collaboration: An Accelerated Path to the Clinic

Pamela Pegman, Ph.D., Senior Principal Scientist, Pfizer, Inc.

Enabling Evaluation of Polysaccharide Size and Content for DOE Studies in Early Process Phases 

Erwin Swennen, Ph.D., Manager, Cell Line and Process Analytics, Bacterial Drug Substance Development, Novartis Vaccines

Developing Cell Lines for Bispecific Antibodies

Martin Bertschinger, Ph.D., Team Leader, Cell Line & Early Process Development, Glenmark Pharmaceuticals

Improving Stability through Vector Design

Thomas Jostock, Ph.D., New Technologies Network Leader / Novartis Leading Scientist, Novartis


USING HIGH-THROUGHPUT TECHNIQUES FOR DEVELOPING CELL LINES

Utilizing High Throughput Bioanalytics for Early Detection of Product Impurities

Christina Alves, Ph.D., Scientist, Biogen Idec, Inc.

High-Throughput Analytical Tools Used for Cell Line Development

Shashi Prajapati, Ph.D., Senior Scientist, High-Throughput Analytical Group, Cell Culture Development, Biogen Idec, Inc.


CHO CELL LINE DEVELOPMENT

Develop Systems Biology Models Based on Whole-Genome Sequencing of CHO to Guide Cell Line Engineering

Nathan Lewis, Ph.D., Assistant Professor, Systems Biology Research Group, University of California, San Diego


CELL LINE DEVELOPMENT FOR BACULOVIRUS

Engineering the Baculovirus Genome for Better Protein Production from Insect Cells

Dominic Esposito, Ph.D., Director, Protein Expression Laboratory, Frederick National Lab for Cancer Research

Optimizing Insect Cell Lines for Production of Structurally Uniform Glycoproteins

Donald Jarvis, Ph.D., Professor, Molecular Biology, University of Wyoming


CLONE SELECTION & OPTIMIZATION

Screening of Mammalian Cell Clones by Mass Balance of Amino Acids

Wen Wang, Ph.D., Postdoctoral Associate of Prof. Daniel I. C. Wang’s group, Chemical Engineering, Massachusetts Institute of Technology (MIT)


DEVELOPING CELL SYSTEMS

Development of Human Cell Systems for Evaluating the Responses of Drugs Directed at Correcting the Function of Cellular Proteins

Dieter Gruenert, Ph.D., Professor, Otolaryngology-Head and Neck Surgery, University of California, San Francisco

 




For more details on the conference,
please contact:

Mary Ruberry
Senior Conference Director
Phone: 781-972-5421
Email: mruberry@healthtech.com 

For exhibit & sponsorship opportunities, please contact: 

Companies A-K:
Elizabeth Lemelin
Business Development Manager
Phone: 781-972-1342
Email: elemelin@healthtech.com 

Companies L-Z:
Sherry Johnson
Business Development Manager
Phone: 781-972-1359
Email: sjohnson@healthtech.com