Engineering of Therapeutic Antibodies



Course Description:
Course Description: Antibody discovery and engineering are integral and essential parts of an antibody drug discovery program. This course will introduce a general work flow of an antibody project from preparation for its launch to having the drug candidates with an emphasis on selecting the proper discovery and engineering tools to achieve the intended goal. Participants of this course will gain a general understanding of the processes and assays that as a whole increase the chance of a successful antibody drug discovery program.


9:00-9:45 Introductory Lecture: Antibody generation project from an antibody engineer’s point of view:


  • Project launch: preparation and evaluation of options.
  • Antibody generation campaigns: discovery and engineering antibody leads.
  • Antibody drug candidate characterization: identification of the ‘best’ drug candidate.

9:45-10:15 Group Exercise: So you want to be an antibody engineer...

10:15-10:30 Refreshment Break

10:30-11:15 Roundtable Discussion Points:


  • Choosing the right strategies for the targets: what tools are in your tool box?
  • Human vs. humanized antibodies: differences and similarities in discovery and engineering.
  • Antibody properties: active engineering vs. passive screens

11:15-12:00 Follow-Up Lecture & Closing Take Home Message


Chung-Ming HsiehTrainer: Chung-Ming Hsieh, Associate Director, Biologics, Abbott Bioresearch Center

Dr. Hsieh currently holds an Associate Director position at the Abbott Bioresearch Center and is responsible for leading a team of scientists to generate and engineer Abbott’s therapeutic antibody candidates in multiple therapeutic areas in collaboration with discovery project teams. Dr. Hsieh received the 2009 Donalee Tabern Outstanding Researcher from Abbott’s Volwiler Society in recognition of his contribution in establishing Abbott’s antibody generation platforms. As a discovery project leader, Dr. Hsieh leads a separate team to develop dual-targeting biologics for autoimmune diseases. Dr. Hsieh has contributed to more than 40 publications in peer-reviewed journals, and is listed as an inventor in multiple US patents and patent applications. Prior to joining Abbott, Dr. Hsieh held a faculty position at the Harvard Medical School and Brigham and Women’s Hospital in Boston where he had previously completed his post-doctoral training. Dr. Hsieh received his Doctor of Science from the Harvard School of Public Health in Biological Sciences and his Bachelor of Science from the National Taiwan University in Zoology.






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