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Thursday, Sept 26, 2013
12:30-1:55 Conference Registration
SCIENCE FOR SUCCESS
1:55 Welcome by Session Chairperson
Guillaume Pfefer, Ph.D., President & CEO, Kala Pharmaceuticals
2:00 A Special Intraocular Contemplation for New Format Antibody Formulations
Dhananjay Jere, Ph.D., Group Leader, PTDE, Hoffmann-La Roche
Development of protein products to target ocular diseases requires special considerations from the molecular designing aspect and also from the formulation, stability, and regulatory aspect. The protein intended to stay in eye has to be compatible and stable in the intraocular environment. This presentation describes key development aspects of new format antibody formulation to make it apt for the intraocular application
2:30 Intrinsic Toxicity Pathways Affecting Survival of Ganglion Cells in Injured Retina
Val Shestopalov, Ph.D., Associate Professor, Ophthalmology, Bascom Palmer Eye Institute, University of Miami Ophthalmology
Aberrant activation of pannexin-1 membrane channel disrupts resilience of these neurons to ischemic, mechanical and other injuries. Mechanistic insights into pathophysiology of pannexin-1 activation suggest that neuroprotective effect strongly correlates with blocking ionic dysbalance and cytokine production. Our results indicate that pharmacological control of pannexin-1 activation can protect against various types of retinal pathologies triggered by ischemic injury, optic nerve stroke and glaucoma.
3:00 Tear Fluid Analysis as a Window into Ocular Health and Disease
Mark W. Duncan, Ph.D., Professor of Medicine, Anschutz Medical Campus, Unviersity of Colorado Denver
We are exploring the potential of tear fluid analysis, especially of peptides and proteins, in defining ocular health and disease by using both targeted and non-targeted analysis strategies. Tear samples (n=10) were collected from subjects (n=40) directly onto a polymeric support following photorefractive keratectomy (PRK). Target proteins were assayed by ELISA (both multiplexed and individual assays) and the samples were also examined by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The relationships between the tear constituents and their quantitative changes follow surgery will be discussed.
3:30 Breakthrough Solutions for Ocular Diseases
Guillaume Pfefer, President & CEO, Kala Pharmaceuticals
Kala is building a diversified pipeline of ophthalmic product candidates: a best-in-class treatment of ocular inflammation and a first-of-a-kind, completely non-invasive wet age-related macular degeneration (AMD) treatment that will transform the industry. We’ll look at the role of technology to create powerful therapies with significantly less cost and risk.
3:45 Refreshment Break with Exhibit & Poster Viewing
4:30 Antibody Fragment Pharmacokinetics in the Eye and Implications for Bi-Specific Therapeutics
Justin Scheer, Ph.D., Senior Scientist, Protein Chemistry, Genentech, Inc.
Although many patients achieve positive vision outcomes in response to ranibizumab, unmet need remains for the majority. We will present recent findings on the ocular pharmacokinetics of various antibody formats and describe advances in our bispecific platform for ophthalmic indication.
5:00 Treating Ocular Disease with Therapeutic Mirror Proteins
Dana Ault-Richie, Ph.D., CEO, Reflexion Pharma
Vascular endothelial growth factor (VEGF) is a protein that when aberrantly expressed stimulates the formation of new blood vessels that contribute to tumor growth and macular degeneration. Reflexion's novel approach uses mirror-image protein technology. Antibodies, like all natural proteins, are "left-handed," meaning that they have a particular orientation in their structure. We have created an unnatural "right-handed" VEGF protein.The beauty of this process is that the "right-handed" end product protein can't be so readily metabolized by the body. Thus lower and less frequent doses are possible, and a reduced side-effect profile (such as immune reactions) is likely.
5:30 Cell-Based Therapies for Ocular Disease
Mohammed El-Kalay, Ph.D., Research and Development, EyeCyte, Inc.
6:00-7:00 Welcome Reception with Exhibit & Poster Viewing
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Cambridge Healthtech Institute
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