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Dr. Renato Skerlj, founder of Drug Discovery Consulting LLC and former Head of Small Molecule Discovery at Genzyme, and CHI's Dr. Edel O'Regan, discuss hot topics in medicinal chemistry including: residence time, covalent inhibition, beyond the rule-of-five, protein-protein interactions, macrocycles. 






Dr. Stewart Fisher, Principal at SL Fisher Consulting and former Executive Director at AstraZeneca, discusses allosteric inhibition, natural product chemistries, covalent inhibition strategies and binding kinetics in drug discovery. 









In part two of his conference preview, Dr. Fisher discusses the importance of receptor binding kinetics and the role of residence time. 







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