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Genomic Tools Summit

Co-located CHI Event:
Genomic Tools & Technologies Summit
June 8-10, 2009
San Francisco, CA





Bio-IT World



Genome Medicine



Science AAAS

The Scientist

RNA Interference Summit - Short Courses



11:30 - 12:00 Short Course Registration

(SC1) Strategies for Effective RNAi Screens

12:00-3:00 pm

The course is designed to provide in-depth information on how to go about setting up RNAi screening experiments and how to design assays for getting optimal results. The challenges working with different types of molecules i.e. siRNAs, shRNAs and the delivery systems to get them into the appropriate cells and tissues will be discussed. The instructors will also provide their input on best practices for the execution of experiments and interpretation of results when dealing with complex biology and informatics.

Topics to be covered:

  • Overview of assay designs for siRNA and shRNA screens
  • Testing and validating methods for RNA delivery
  • Use of appropriate reagents and cell types
  • Implementing proper quality control
  • Minimizing cytotoxicity and off-target effects
  • Data analysis and statistical considerations


Christophe J. Echeverri, Ph. D., CEO/CSO, Cenix BioScience GmbH

Marc Ferrer, Ph.D., Senior Research Fellow, Automated Biotechnology, Merck & Co.


(SC2) Strategies for Optimizing RNAi Delivery

3:30-6:30 pm

The course is designed to provide both the beginner and the expert, with a comprehensive overview of current and emerging delivery systems and formulations facilitating RNAi delivery. Various methods for RNAi delivery such as viral vectors, liposomes, nanoparticles, chemical conjugates and other commonly used techniques will be compared and contrasted for different applications. The instructors will also discuss the challenges associated with RNAi delivery, both in vitro and in vivo, and offer guidance based on their knowledge and expertise in the field.

Topics to be covered:

  • Testing and validating methods for delivery
  • Overview of viral and non-viral vector systems
  • Chemical methods of improving delivery
  • New formulations to optimize delivery
  • Minimizing cytotoxicity and off-target effects
  • Examining tissue distribution and safety profiles


Muthiah Manoharan Ph.D., Vice President, Drug Discovery, Alnylam Pharmaceuticals

Roger Adami, Ph.D., Associate Director, Molecular Pharmaceutics, MDRNA Inc.

John Rossi, Ph.D., Professor and Chair, Molecular Biology, Beckman Research Institute of the City of Hope

Namjin Chung, Ph.D., Senior Research Investigator, Applied
Genomics, Bristol-Myers Squibb

For more conference information, please contact:

Tanuja Koppal, Ph.D.
Conference Director
Cambridge Healthtech Institute
Phone: 973-525-4667
Email: tkoppal@healthtech.com

For partnering and sponsorship information, please contact:
Jon Stroup
Manager, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5483
Email: jstroup@healthtech.com

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