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Digital Course: A Practical Guide to Finding Regions of Chromosomal Copy Number Gain or Loss




CONFERENCE SERIES: Genomics
Recorded at: XGen Congress
 

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Digital Course: A Practical Guide to Finding Regions of Chromosomal Copy Number Gain or Loss

March 15, 2010


About this Product:
This digital course will compare and contrast different methods used to find regions of copy number change and provide a practical guide to finding and validating these genomic regions.

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About the Conference:
The resulting applications of newly developed whole-genome scanning technologies have catalyzed the appreciation of copy number variation (CNV) in the genomic community. Studies linking insertions, deletions, and inversions to disease etiology continue to multiply. As genome-wide scanning techniques become more widely used in diagnostic laboratories, the major challenge is how to accurately interpret which variations are pathogenic in nature and which are benign.

Agenda at a Glance:
The increased popularity and simplification of large scale gene expression experiments have enabled many scientists to incorporate comparative genomics into their routine experimentation. With the increased availability of SNP arrays, large scale assays to measure differences in abundance of genomic DNA are now available; however, the analysis methods are not as mature as methods to identify differentially expressed genes. This course will compare and contrast different methods used to find regions of copy number change and provide a practical guide to finding and validating these genomic regions.

Topics to be covered include: 

  • How copy number and expression assays are similar as well as different
  • A detailed description of at least one method of identifying breakpoints and regions of common copy number
  • A guide to some key filtering tools to limit and narrow a lengthy list of genomic segments with aberrant copy number
  • Visualizing copy number data at a variety of levels


Instructors:
Tom DowneyThomas J. Downey, President, Partek, Inc.

Biography: Tom Downey is the President and CEO of Partek Incorporated in St. Louis, Missouri. He has been a Partek employee since 1993, and he has over twenty years of experience in computer and electrical engineering and data analysis. Downey has been published in journals including as Genetic Epidemiology and Genome Biology.

Min LiMin Li, Ph.D., Field Application Scientist, Partek, Inc.

Biography: Dr. Min Li is a field application scientist from Partek Incorporated. She got her Ph.D. from the Ohio State University in 2008 and has been focused on gene expression and copy number variation data analysis since then.

About this Product:
3 Presentations
Over 83 slides
156 minutes
Single Copy - $345.00
Site License - $1,380.00



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