Cambridge Healthtech Institute’s Second Annual  

Epigenomics in Disease  

Above the Genome - Underlying Disease

February 16-18, 2015 | Moscone North Convention Center | San Francisco, CA
Part of the 22nd Annual Molecular Medicine Tri-Conference


It is now universally recognized that dysregulation of the regulatory layers above the genome— namely the epigenome — produces aberrant gene expression leading to disease. With advances in sequencing technologies, drivers and mechanisms of disease initiation are being unraveled, and a more holistic view of the interplay between the genome and a very active epigenome is taking shape. Importantly, these findings form inextricable causal links between our underlying genome, the regulatory epigenome, and the functional (disease) consequence stemming from both.

The Epigenomics in Disease meeting will gather leading researchers advancing our understanding of the epigenetic contributors to disease, explore novel approaches and technologies for interrogation, and discuss the utilization of epigenomic analysis for personalized diagnostics and treatment.

advances in Interrogating (Epi)Genomes

Keynote Presentation: Regulatory Genomics and Epigenomics of Complex Disease

Manolis Kellis, Ph.D., Professor, Computer Science, MIT; Director, Computational Biology Group, Computer Science and Artificial Intelligence Lab (CSAIL), Broad Institute of MIT and Harvard

Shaping the Blood: Lessons from Chromatin and Single Cell RNA Dynamics

Ido Amit, Ph.D., Associate Professor, Immunology; Principal Investigator, Laboratory for Immuno-Genomic



Co-Dependency of the Genome and Epigenome during Tumor Evolution

Joseph Costello, Ph.D., Professor in Residence, Department of Neurological Surgery; Director, Epigenetics Division, Cell Cycling and Signaling Program, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco

Epigenome-Wide Landscape of Melanoma Progression to Brain Metastasis

David Hoon, Ph.D., Chief, Scientific Intelligence, Director, Molecular Oncology, John Wayne Cancer Institute

Epigenetic “Addiction” in Pediatric Brain Tumors: A Tale of a Histone Tail

Nada Jabado, M.D., Ph.D., Associate Professor, Pediatrics; Associate Member, Department of Human Genetics, Oncology and Experimental Medicine, McGill University

Genetic-Epigenetic Interactions in Cis and Trans: Relevance to the Human Brain and Immune System

Benjamin Tycko, M.D., Ph.D., Professor, Pathology and Cell Biology, Institute for Cancer Genetics &Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University


Featured Presentation: Epigenome Remodelling and DNA Replication Timing: What are the Implications in Cancer?

Susan Clark, Ph.D., Professor & Director, Epigenomics Centre, The Kinghorn Cancer Centre, Garvan Institute of Medical Research

Linking Histone Recognition to the Epigenetic Inheritance of DNA Methylation

Brian Strahl, Ph.D., Associate Professor & Director, Graduate Studies of Biochemistry & Biophysics, University of North Carolina School of Medicine

Remodeling the Remodelers: BAF Complex Structure and Function in Human Malignancy

Cigall Kadoch, Ph.D., Principal Investigator, Pediatric Oncology, Dana-Farber Cancer Institute; Assistant Professor, Department of Pediatrics, Harvard Medical School


Highly Sensitive Methods for Analysis of the “Accessible Genome”

William James Greenleaf, Ph.D., Assistant Professor, Department of Genetics, Stanford University School of Medicine

Hybridization-Based Epigenotyping Using Methyl Binding Domains for Routine Clinical Analyses

Hadley D. Sikes, Ph.D., Joseph R. Mares Assistant Professor, Chemical Engineering, Massachusetts Institute of Technology


DNA Methylation as Cancer Biomarkers in Clinical Development

David Shames, Ph.D., Senior Scientist, Genentech

Development of DNA Methylation Markers for Early Lung Cancer Detection

Ite A. Laird-Offringa, Ph.D., Director, Biomedical and Biological Sciences; Associate Professor, Surgery, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California

Quantitative and Sensitive Bisulfite-Free DNA Methylation Analysis from FFPE Tissues: Application to an 8-Gene Clinical Test for Brain Cancer Prognostics

Michelle M. Hanna, Ph.D., CEO & Scientific Director, RiboMed Biotechnologies, Inc.


3D Genome Conformation and Gene Transcription Regulation in Human Diseases

Yijun Ruan, Ph.D., Professor and Director, Genome Sciences, Jackson Laboratory Genomic Medicine

New Avenues for Studying Gene Regulation in Clinical Cancer Research using DNA Methylation Sequencing

Benjamin P. Berman, Ph.D., Assistant Professor, Division of Bioinformatics, Department of Preventive Medicine; Member, USC Epigenome Center, University of Southern California

Interactive and Exploratory Visualization of Epigenome-Wide Data

Héctor Corrada Bravo, Ph.D., Assistant Professor, Department of Computer Science, UM Institute for Advanced Computer Studies & Center for Bioinformatics and Computational Biology, University of Maryland


Control of Cell Differentiation and Phenotype by 5-Hydroxymethylcytosine

Lucy A. Godley, M.D., Ph.D., Associate Professor, Department of Medicine, Section of Hematology/Oncology, Cancer Research Center, The University of Chicago

DNA Methylation in Cancer and Other Human Diseases

Taiping Chen, Ph.D., Associate Professor, Department of Molecular Carcinogenesis, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center

Heritability of Epimutations in Cancer-Prone Families

Megan Hitchins, Ph.D., Associate Professor, Department of Medicine, Division of Oncology, Stanford School of Medicine



For more details on the conference, please contact:
Kip Harry
Conference Director
Cambridge Healthtech Institute
T: (+1) 781-972-5454

For partnering and sponsorship information, please contact:
Jon Stroup (Companies A-K)
Manager, Business Development
Cambridge Healthtech Institute
T: (+1) 781-972-5483

Joseph Vacca (Companies L-Z) 
Manager, Business Development
Cambridge Healthtech Institute
T: (+1) 781.972.5431



  2015 Plenary Sessions 

2015 MMTC Prelim Agenda 

Premier Sponsors:


Jackson Laboratory - small logo 

Leica Biosystems 




Thomson Reuters-Large 

Local Partners:




City of SSF