January 18-22, 2016 | Town and Country Resort Hotel | SAN DIEGO, CA 
January 18-22, 2016 | Town and Country Resort Hotel | SAN DIEGO, CA 

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Cambridge Healthtech Institute’s 8th Annual
Engineering Genes, Vectors, Constructs and Clones
Upstream Decisions Lead to Downstream Success
January 18-19, 2016


Engineering therapeutic protein expression platforms is not for the faint of heart. Many variables must be considered during the engineering process, including verification and sequence analysis of the gene or protein of interest, codon optimization, vector construction and clone / host selection. When challenges arise, protein expression engineers must design new cloning schemes by altering the DNA or amino acid sequence, moving a gene from one vector to another, transfecting the vector to an alternative host, re-selecting the clone, re-characterizing the expressed protein or any of the above – a laborious, time-consuming and expensive process.

Cambridge Healthtech Institute’s 8th Annual Engineering Genes, Vectors, Constructs and Clones conference continues the tradition of applying effective engineering strategies for protein expression and production research leading to functional biotherapeutic products. Learn from seasoned, savvy researchers as they share their real-world experiences, applications and results.

Preliminary Agenda 


KEYNOTE PRESENTATION
Use Integration Defective Lentiviral Vectors to Measure the Off-Target Effect of Gene Editing

Jiing-Kuan Yee, Ph.D., Professor, Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center


GENOME ENGINEERING

Strain Engineering to Prevent Norleucine Incorporation during Recombinant Protein Production in Escherichia coli 

Karthik Veeravalli, Ph.D., Senior Engineer, Late Stage Cell Culture, Genentech, Inc.

Expediting Protein Biomanufacturing through the UCOE Gene Expression Platform

Michael Antoniou, Ph.D., Reader, Molecular Genetics, Medical & Molecular Genetics, King's College London

Luncheon Presentation: Engineering Biological Systems from Genes to Genomes

Mark Welch, Ph.D., Vice President, Research and Development, DNA 2.0


VECTOR DESIGN

Expression Vector and Gene Engineering: Approaches to Improve Recombinant Protein Production in CHO Cells

Janice Tan, Ph.D., Research Scientist, Bioprocessing Technology Institute, A*STAR

Selecting the Optimal Vector for High-Throughput Cloning and Protein Arrays

Andrea Throop, Ph.D., Production Manager, Center for Personalized Diagnostics, Biodesign Institute, Arizona State University

Development of Effective Expression Systems for the Production of Glycosyltransferases Used in the Glycoengineering of Biotherapeutics

James Meador, Senior Scientist, Protein Production, Research, Momenta Pharmaceuticals, Inc.


 

CODON OPTIMIZATION

Computational Design Strategies for Synthesizing Genes and Fusion Proteins and Enhancing their Expression

Dong-Yup Lee, Ph.D., Assistant Professor, Chemical and Biomolecular Engineering, National University of Singapore; Senior Scientist, Bioprocessing Technology Institute, A*STAR

A Systematic Approach to Engineering Antibody and Integral Membrane Protein Expression

James D. Love, Ph.D., Director, Technology Development, Biochemistry, Albert Einstein College of Medicine




For questions about the meeting, please contact: 

Mary Ann Brown
Executive Director, Conferences
Cambridge Healthtech Institute
Phone: 781-972-5497
Email: mabrown@healthtech.com 

For partnering & sponsorship information, please contact: 

Companies A-K
Jason Gerardi
Manager, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5452
Fax: 781-972-5470
Email: jgerardi@healthtech.com 

Companies L-Z
Carol Dinerstein
Director, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5471
Fax: 781-972-5470
Email: dinerstein@healthtech.com