Immunogenicity Summit

PK/PD of Novel Constructs 

Understanding the metabolism of novel constructs in animal models and clinical studies is critical to their success. This year’s conference will cover the role of PK in optimizing novel constructs, look at opportunities for improvement of ADCs, share examples of implementing mechanistic modeling to inform drug design, and review the state-of-the-art for applying multi-specific medicines. The goal of this meeting will be to develop successful PK/PD principles and apply them to translating candidates from preclinical development to the clinic.

Topics to be covered include:

  • Optimizing novel constructs through PK engineering
  • Improving ADC pharmacology
  • T-cell engaging bispecifics in vivo 
  • Case studies and engineering solutions
  • PK in the clinical setting for ADCs and bispecifics
  • Design of new modalities through mechanistic modeling
  • First-in-human (FIH) dose selection
  • Regulatory perspective on new modalities
  • Predictive data sets from animal models
  • Trends in quality attributes that impact PK

If you are interested in presenting, please click here to submit a speaking proposal for review. Please note that due to limited speaking slots, preference is given to abstracts from those within pharmaceutical and biotech companies, regulators and those from academic centers. Additionally, in accordance with CHI policy, a select number of vendors/consultants who provide products and services to these biopharmaceutical companies are offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

All proposals are subject to review by the Scientific Advisory Committee to ensure the highest quality of the conference program.


Deadline for submission is May 3, 2013.

We truly welcome your comments, suggestions and speaker referrals as we shape the 2013 program.

For questions or suggestions about the meeting, please contact:

Christina Lingham
Executive Director, Conferences
Cambridge Healthtech Institute
Phone: 781-972-5464
Email: clingham@healthtech.com      

For exhibit and sponsorship opportunities, contact:
Tim McLucas
Business Development Manager
Cambridge Healthtech Institute
Phone:  781-972-1342
Email: tmclucas@healthtech.com 

For marketing and media partnerships, please contact:
Pete DeOlympio
Marketing Manager
Cambridge Healthtech Institute
Phone: 781-972-5415
Email: peted@healthtech.com