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The drug discovery landscape is rapidly changing and with it comes the need to generate leads with lower attrition rate. A property-based drug design approach is guiding researchers in designing candidates with the right balance of physicochemical properties - safety and absorption, distribution, metabolism, and excretion (ADME) profiles. The fourth annual Property-Based Drug Design in Medicinal Chemistry conference will bring together experts and leaders from industry and academia to share strategies and case studies for new and non-traditional molecules, how computational modeling and data management can be used effectively, and to discuss novel ways to measure or predict properties to make molecules more drug-like and overcome challenges in discovery, development, and the clinic.

The annual conference will feature stimulating discussions, informative and high quality case studies and a friendly place to network with peers. We invite you to present a talk, a poster, or to attend to learn from and network with the leading experts from around the globe.

Who should attend: Vice Presidents, Directors and Chemists/Scientists specializing in Discovery Chemistry, Medicinal Chemistry, Pharmacokinetics Dynamics & Metabolism (DMPK), Early Pharmaceutics, Computational Chemistry, Analytical Sciences, Physical Chemistry, Drug Research and Technologies, Small Molecule Drug Discovery, Chemical and Pharmaceutical Profiling

The scope of the conference includes but is not limited to the following topics: 

Case Studies and Future Directions for Property Based Structure Design Consideration for New and Non-Traditional Molecules 

  • Peptide-based drugs
  • Macrocyclics
  • Tough enzyme targets
  • Covalent drugs
  • Fragment-based drug design
  • Linker design
  • Antibody-drug conjugates

Computational Modeling and in silico Prediction of Drug Properties 

  • Property-based structure optimization tools
  • Data management and analysis in drug discovery

New and Novel Ways to Predict and Evaluate Properties 

  • Solubility, co solvent solubility, crystal forms, logP, permeability, absorption, association/dissociation constants, ligand efficiency 


Designing the Right Balance of Properties to Overcome Challenges in Discovery, Development, and the Clinic 

  • Physicochemical properties affecting pharmacodynamics/pharmacokinetics
  • Using DMPK knowledge for better drug design
  • Exploitation of transporter

Designing Molecules with Improved Drug Properties for Better Deliverability and Targeting 

  • Drug design consideration for CNS drug and blood brain barrier penetration
  • Targeting tissues and specific cells
  • Nanoparticles, liposomes, antibody-drug conjugates

If you would like to submit a proposal to give a presentation at this meeting, please click here.

The deadline for submission is November 14, 2014. 

All proposals are subject to review by the Scientific Advisory Committee to ensure the highest quality of the conference program. Please note that due to limited speaking slots, preference is given to pharmaceutical and biotech companies, regulators and those from academia. Additionally, vendors/consultants who provide products and services to these biopharmaceutical companies are offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships. 

For questions about the meeting, please contact:
Nandini Kashyap
Conference Director
Cambridge Healthtech Institute
T: 781-972-5406

For sponsorship and exhibit information, contact:
Joseph Vacca
Associate Director, Business Development
Cambridge Healthtech Institute
T: (+1) 781-972-5431

WPC Colocated Event 

Submit Speaker Proposal 




The exhibit hall has sold out the past four years, so please contact us early to reserve your place. To customize your sponsorship or exhibit package for 2015, contact:

Joseph Vacca
Associate Director, Business Development