Cambridge Healthtech Institute’s 6th Annual
Protein Aggregation and Emerging Analytical Tools
Mechanism, Prediction, Screening, Immunogenicity and Formulation Challenges
January 22-23, 2015
The popular Protein Aggregation and Emerging Analytical Tools conference covers latest trends, challenges and solutions in protein aggregation. It features in-depth case studies and interactive discussions on mechanisms of aggregation, detection and quantitation of aggregates and detection and analysis techniques. It also presents case studies on prevention of particle formation by engineering and formulation approaches, impact of aggregation on production, aggregates as a factor for immunogenicity and approaches for improvement of biophysical properties of protein solutions.
We invite you to join colleagues from around the world in this discussion of the key challenges and solutions in protein aggregation, and see how experts like you are overcoming analytic, formulation, manufacturing and regulatory challenges to create a stable formulation.
Protein-Solvent Interaction and its Importance to Solubility and Viscosity
Thomas Laue, Ph.D., Professor, Biochemistry and Molecular Biology; Director, Biomolecular Interaction Technologies Center (BITC), University of New Hampshire
Aggregation of Antibody CH2 Domains and Antibody-Drug Conjugates
Dimiter S. Dimitrov, Ph.D., Senior Investigator, Protein Interaction Group, FNLCR, NCI, National Institutes of Health
Stable Human IgG Therapeutics through Engineering of Antibody Variable Domains
Daniel Christ, Ph.D., Head Antibody Therapeutics, Immunology, Garvan Institute of Medical Research
Light-Induced Degradation of Antibodies and Antibody-Drug Conjugates
Christian Schöneich, Ph.D., Professor and Chair, Pharmaceutical Chemistry, University of Kansas
Approaches to Separately Predict Aggregation Mechanisms and Shelf Life
Christopher J. Roberts, Associate Professor, Department of Chemical & Biomolecular Engineering, University of Delaware
The Simultaneous Determination of the Extent and Mechanism of Aggregation and the Stability of Proteins as Key Factors to Be Considered in Developability
Belinda Pastrana, Ph.D., Full Professor, Chemistry, University of Puerto Rico
Microscalethermophoresis: A New Tool for High Throughput Protein Stability Prediction?
Gerhard Winter, Ph.D., Professor, Chair of Pharmaceutical Technology and Biopharmaceutics, LMU Munchen
Characterization of Protein Aggregate Structure with SAXS
Anette Henriksen, Ph.D., Principal Scientist, Protein Biophysics and formulation, Novo Nordisk
Talk Title to be Announced
Leena Philominathan, Ph.D., Scientist, Alexion, Inc.
Protein Aggregate Size: A Potentially Important Factor in Inducing an Immune Response in Both in vitro and in vivo Model Systems
Marisa K. Joubert, Ph.D., Senior Scientist, Process & Product Development, Amgen, Inc.