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Cambridge Healthtech Institute’s 6th Annual
Protein Aggregation and Emerging Analytical Tools
Mechanism, Prediction, Screening, Immunogenicity and Formulation Challenges
January 22-23, 2015


The popular Protein Aggregation and Emerging Analytical Tools conference covers latest trends, challenges and solutions in protein aggregation. It features in-depth case studies and interactive discussions on mechanisms of aggregation, detection and quantitation of aggregates and detection and analysis techniques. It also presents case studies on prevention of particle formation by engineering and formulation approaches, impact of aggregation on production, aggregates as a factor for immunogenicity and approaches for improvement of biophysical properties of protein solutions.

We invite you to join colleagues from around the world in this discussion of the key challenges and solutions in protein aggregation, and see how experts like you are overcoming analytic, formulation, manufacturing and regulatory challenges to create a stable formulation.

Preliminary Agenda 


UNDERSTANDING PROTEIN INTERACTIONS FOR BETTER PRODUCT DESIGN AND DEVELOPMENT  

Protein-Solvent Interaction and its Importance to Solubility and Viscosity 

Thomas Laue, Ph.D., Professor, Biochemistry and Molecular Biology; Director, Biomolecular Interaction Technologies Center (BITC), University of New Hampshire 

Aggregation of Antibody CH2 Domains and Antibody-Drug Conjugates  

Dimiter S. Dimitrov, Ph.D., Senior Investigator, Protein Interaction Group, FNLCR, NCI, National Institutes of Health 

Stable Human IgG Therapeutics through Engineering of Antibody Variable Domains 

Daniel Christ, Ph.D., Head Antibody Therapeutics, Immunology, Garvan Institute of Medical Research 

Light-Induced Degradation of Antibodies and Antibody-Drug Conjugates 

Christian Schöneich, Ph.D., Professor and Chair, Pharmaceutical Chemistry, University of Kansas  


PROTEIN AGGREGATION AND PRODUCT STABILITY: PREDICTION, RAPID SCREENING AND NEW TOOLS 

Approaches to Separately Predict Aggregation Mechanisms and Shelf Life 

Christopher J. Roberts, Associate Professor, Department of Chemical & Biomolecular Engineering, University of Delaware 

The Simultaneous Determination of the Extent and Mechanism of Aggregation and the Stability of Proteins as Key Factors to Be Considered in Developability 

Belinda Pastrana, Ph.D., Full Professor, Chemistry, University of Puerto Rico 

Microscalethermophoresis: A New Tool for High Throughput Protein Stability Prediction? 

Gerhard Winter, Ph.D., Professor, Chair of Pharmaceutical Technology and Biopharmaceutics, LMU Munchen 

Characterization of Protein Aggregate Structure with SAXS 

Anette Henriksen, Ph.D., Principal Scientist, Protein Biophysics and formulation, Novo Nordisk 

Talk Title to be Announced  

Leena Philominathan, Ph.D., Scientist, Alexion, Inc.  


AGGREGATION OF PROTEIN IN VIVO: IMPACT ON SAFETY, EFFICACY AND IMMUNOGENICITY 

Protein Aggregate Size: A Potentially Important Factor in Inducing an Immune Response in Both in vitro and in vivo Model Systems 

Marisa K. Joubert, Ph.D., Senior Scientist, Process & Product Development, Amgen, Inc.