Peripheral Blood Biomarkers for Brain Damage - Challenging but Feasible

October 16, 2012
11:30 am – 12:30 pm EDT


Sponsored by

Simoa Science 


Symposium Course Description: Professor Henrik Zetterberg will provide an overview on the need for reliable biochemical markers to evaluate CNS injuries. The past two decades have seen successful development of cerebrospinal fluid biomarkers, but it has been much more difficult to find biomarker signatures in the blood that reliably signal CNS damage. The major problem is the low abundance of CNS-derived proteins in the blood stream. Professor Zetterberg will discuss new studies on blood biomarkers for neuronal injury and specifically report data from new Simoa-based measurements in sports-related concussion and ischemic brain damage. Blood biomarkers for neuronal injury would be extremely useful in a variety of settings ranging from the clinical management of children with mild head trauma in the playground to highly prevalent neurodegenerative conditions in the elderly. The Simoa technology platform has broad applicability for the detection of low abundance biomarkers in neurology and beyond.

Learning Objectives:

  • Understand Single Molecule Array (Simoa) technology and its application for basic, translational and clinical researchers who wish to quantify and validate low abundance protein biomarkers, including neurological markers in peripheral blood

Who Will Benefit:

  • Laboratories currently utilizing immunoassays for discovery, preclinical studies and clinical trials that desire the highest sensitivity and precision, the ability to generate data rapidly for increased productivity, and multiplex using small sample volumes
  • Researchers and clinicians specializing in Assay Development, Biomarkers, CNS, Diagnostics, Personalized Medicine, Proteins and Proteomics, Translational Medicine

Program Agenda: 

1. Introduction to Quanterix Single Molecule Array (Simoa) technology (15 min)

  • Presentation by Dr. David Duffy, Quanterix Corporation

2. Application of Simoa to Measure Low Abundance Neuronal Proteins (30 min)

  • Presentation by Dr. Henrik Zetterberg, University of Gothenburg, Sweden

3. Q&A (5-10 min)

Speaker #1 Information::

David DuffyDavid Duffy, Ph.D.
Vice President, Research
Quanterix Corporation
113 Hartwell Avenue
Lexington, MA 02421
Tel: 617-301-9412

Speaker #2 Information::

Henrik ZetterbergHenrik Zetterberg, MD, Ph.D.
Head of the Department of Psychiatry and Neurochemistry
University of Gothenburg, Sweden
Tel: +46 31 3430142

By Series:
By Region: