A Light Scattering Toolbox for the Biophysical Characterization of Virus-Like Particles (VLPs)



February 5, 2014
11:00 am-12:00 pm EST

 

Sponsored by
Wyatt Tech
 

Symposium Course Description:

The analytical challenges associated with R&D and manufacturing of VLPs include reliable and repeatable determination of structure and payload, activity, quantitation, process optimization, high-throughput assessment of formulation conditions, and stability under stress. Light scattering helps meet these challenges by providing key tools for characterizing the essential biophysical parameters of VLPs. This webinar discusses the application of multi-angle static light scattering (MALS) and dynamic light scattering (DLS) to VLP characterization, both in batch (unseparated) mode and in conjunction with separation by size-exclusion chromatography (SEC-MALS-DLS) and field-flow-fractionation (FFF-MALS-DLS).

Learning Objectives:


  • Learn the primary attributes of static and dynamic light scattering (MALS and DLS) for the physical characterization of biomaterials
  • Compare the utility of size exclusion chromatography with field flow fractionation for VLP and other nanoparticle separations
  • Find out which VLP properties are uniquely determined by on-line MALS and DLS, and which are amenable to screening by high-throughput DLS
  • Have your questions about light scattering and VLP characterization answered by an expert scientist


Speaker Information:


John Champagne, PhD.
Senior Applications Scientist
Wyatt Technology Corporation



Download Webinar  

By Series:
By Region: