Antibody Design and Humanization via Rational in silico Modeling


March 12, 2013
11:30 am – 1:00 pm EST

 

 

Symposium Course Description:

Recent advances in antibody homology modeling have led to the creation of different strategies to design, engineer, and affinity mature as well as humanize antibodies. In silico modeling not only helps in better antibody design but also saves time from predictions to validation.

Learning Objectives: 

  • Create antibody homology model from the primary sequence
  • Force field energy minimizations
  • Steric clashes within the humanized antibody and rational methods to fix it

Who Should Attend:

Students, Post-doctoral fellows, Scientists and anyone who does or interested in antibody design, engineering, affinity-maturation and recent advances in humanization of antibodies will gain.

Instructor Information:

Vinodh Kurella, Ph.D., Visiting Research Fellow, C3 Bioinformatics, Harvard Medical School

Instructor Biography:

Vinodh Kurella Vinodh Kurella is a protein/antibody engineer with focus on humanization, who uses computational modeling based approach to design, engineer, affinity mature and humanize antibodies. Before completing post-doctoral training at Dana Farber Cancer Institute, received PhD from Dept. of Biochemistry at LSU Health Sciences Center in the field of protein X-ray crystallography.





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