Upcoming Global Web Symposia
December 3, 201311:00 am to 12:00 pm EST
Symposium Course Description:
While the application of sophisticated computational techniques has provided novel ways of evaluating genomic data, its intricacies may obscure the ultimate objective of providing translational scientists and clinicians with easily understandable, accurate and actionable endpoints. Following a brief review of genomic fundamentals, this symposium will compare and contrast different analytical approaches to genomic data and present a novel approach that provides users with clear, reproducible, and meaningful practical outcomes.
Who Should Attend:
1. Introduction to genomics (10 minutes)
2. Standard methods for genomic analysis – a critical comparison of candidate gene and GWAS approaches (10 minutes)
3. How learned networks of cooperating SNPs and genes are developed (15 minutes)
4. Examples of how SNP or gene clusters and networks can inform our pre-clinical and clinical decision making (15 minutes)
5. Conclusions (5 minutes)
6. Q+A (10 minutes)
Stephen T. Sonis, D.M.D., D.M.Sc.
Founder, Partner, Chief Scientific Officer
Dr. Sonis is a world-renowned expert in epithelial injury associated with cancer therapy. His development of predictive animal models has enabled the investigation of the biological basis of mucositis and has assisted in the development of potential therapies. The results of his studies on the molecular and cellular pathogenesis of mucositis have established the basis of the mechanistic paradigm for mucosal injury. Dr. Sonis’ interest in the genomic basis for toxicity risk and its pathology has led to innovative genomics-based analytical approaches to clinically actionable outcomes to personalize disease therapy. These studies have resulted in the identification of drug and toxicity specific SNP and gene networks which identify individuals at risk of treatment toxicities and define the genomic parameters which differentiate patients who respond to a specific drug treatment from those who do not.
Dr. Sonis has published extensively on the clinical, biological, and health economic aspects of cancer and complications associated with its treatment. He is the author of over 200 original publications, reviews and chapters, 10 books, and 5 patents. Dr. Sonis has obtained degrees from Tufts University and Harvard University and completed his post-doctoral education (tumor immunology) at Oxford University. He holds appointments at the Harvard School of Dental Medicine (Clinical Professor of Oral Medicine, Department of Oral Medicine, Infection and Immunity), the Dana-Farber Cancer Institute and Brigham and Women’s Hospital where he is Division Chief and Senior Surgeon.
Gil Alterovitz, PhD
Biomodels Senior Genomics Consultant
Dr. Alterovitz acts as a consultant for analysis of genomic data. His interest in bridging the fields of engineering and medicine led him to develop a Bayesian and information theoretic framework for genomics research. The outcome is the ability to discover hidden relationships in networks which expose global connectivity patterns. This method is widely applicable to areas of personalized genomics and pharmacogenomics. Dr. Alterovitz is currently an Assistant Professor at the Harvard Medical School. He received his Ph.D. in electrical and biomedical engineering and masters in electrical engineering and computer science from the Massachusetts Institute of Technology. He also holds a B.S. in electrical and computer engineering from Carnegie Mellon University.
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