Today, biospecimen collections are used by multiple groups for various aims, from basic research through clinical trials. A well-managed biobank is a critical prerequisite for high-quality biological research. The proper collection, processing, storage, and tracking of biospecimens are vital components allowing researchers to better link molecular and clinical information. Thus, by necessity, biobanking is both a science and a business. Cambridge Healthtech Institute’s fourth annual Leaders in Biobanking Congress addresses both the business and science of biobanking, bringing together biomedical and biopharmaceutical researchers, regulators, biorepository managers, and practitioners to investigate the best tactics for effective use of biospecimens within today’s cutting edge research.
Key Features
- PRESENTATIONS
Gain insight from biobanking managers and biopreservation scientists and delve into the molecular advances in biomedical science.
- PANEL DISCUSSIONS
Determine best practices in biopreservation protocols.
- CASE STUDIES
Analyze ongoing biobanking partnerships.
- NETWORKING OPPORTUNITIES
Join discussion groups and dedicated exhibit hall and poster viewing hours.
- SHORT COURSES
Attend interactive courses designed as a great introduction for those who are new to a particular discipline or as a refresher for those who want to brush up on their knowledge or expand their horizons.
Co-Hosted by
Includes an Onsite Tour of LabCorp’s Center for Molecular Biology & Pathology (CMBP) in the Research Triangle Park
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Collaboration and Biospecimen Sharing between Multiple Biorepositories
Few biorepositories contain sufficient numbers of samples to perform large research studies, necessitating collaboration between multiple sites. The mass availability of high-quality biological specimens for research requires the development of standardized methods for collection, long-term storage, retrieval and distribution. The use of standard operating procedures (SOPs) is fundamental and widespread. However, standardized data collection, rigorous data management, and uniformed informed consent procedures are becoming increasingly valuable for collaboration between researchers in this network. This workshop is designed to discuss a new standard for successful collaboration, providing scientists and clinicians with methods to simplify specimen sharing, with complete phenotypic and clinical information associated with samples.
Instructors:
Alex Sherman, Ph.D., Director, Systems, Neurology, Massachusetts General Hospital
Additional Instructors to be Announced
Lessons Learned: Where Are We Now? Where Are We Going?
Biobanking Initiatives at Duke
Helena Ellis, Director, Duke Biobank, Duke Translational Medicine Institute, Duke University
Designing and Implementing a Centralized, Publicly Accessible, Linked Sample-Clinical Data Repository
Philip Cooley, Fellow, Bioinformatics and High-Performance Computing, RTI International
Developing a Tissue Biospecimen Resource Center at the Cleveland Clinic
Angen Liu, M.D., Ph.D., Medical Director, Tissue Biospecimen Resource Center; Associate Staff, Anatomic Pathology, Cleveland Clinic
Challenges and Obstacles in Locating and Obtaining Rare Disease Specimens
Yaffa Rubinstein, Ph.D., Director of Patient Resources for Clinical and Translational Research
Office of Rare Diseases Research, (ORDR), National Center for Advancing Translational Sciences (NCATS)
What is the Value of a Clinical Sample?
What’s in Your Sample?
Sample Quality – the Key to Success or Failure
Catherine A. Hammett-Stabler, Ph.D., DABCC, FABC, Professor, Department of Pathology and Laboratory Medicine, University of North Carolina
Pre-Analytical Variables of Specimen Processing in Molecular Diagnostics
Helen D. Fernandes, Ph.D., Director, Molecular Diagnostics; Associate Professor, Department of Pathology & Laboratory Medicine New Jersey Medical School (invited)
Impact of Preanalytic Factors on the Design and Application of Integral Biomarkers for Directing Patient Therapy
Stephen Hewitt, M.D., Ph.D., Clinical Investigator, Pathology, National Cancer Institute, NIH
Biospecimen Quality Control for Sequencing Applications
Belynda D. Hicks, Director, Quality Management, Genetics and Genomics, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick
Application of Pattern Recognition Image Analysis for Improved Research-Appropriate Biobanking Specimen QA
R. Mark Simpson, Ph.D., D.V.M., Senior Scientist, Laboratory of Cancer Biology and Genetics; Head, Comparative Molecular Pathology Unit, National Cancer Institute
Development of Sample Biorepository for the TRIBE-AKI Consortium
Chirag Parikh, M.D., Ph.D., Director, Translational Research Program, Section of Nephrology, Yale University School of Medicine
Reference Samples – Who Needs Them? (We All Do)
Building Assay-Ready Tools for Research and Industry
Belinda J. Wagner, Ph.D., Senior Director, BioCollections and Standards, American Type Culture Collection (ATCC)
LabCorp: Improving Patient Care through Characterized Sample Sets
Hannah Maynor, Associate Director, Biorepository, Laboratory Corporation of America
Whole-Exome Sequencing of DNA from Peripheral Blood Mononuclear Cells (PBMC) and EBV-Transformed Lymphocytes from the Same Donor
Eric Londin, Ph.D., Fellow, Computational Medicine Center, Thomas Jefferson University
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Where is the Value of a Clinical Sample?
Drug Discovery and Development
Retrospective Analysis: Contribution and Implementation in Drug Development
Amelia Warner, Pharm.D., Head, Clinical Pharmacogenomics and Clinical Specimen Management, Global Clinical Development and Regulatory Affairs, Merck
Novartis Translational Research Initiative: Taking BioBanking to Early Pharmaceutical Research
Dmitri Mikhailov, Ph.D., Associate Director, Translational Medicine, Novartis
Optimizing PGx Collection in Clinical Trials
Anita Nelsen, Director, R&D Human Sample BioRepository & Genetics Sample Acquisition, GlaxoSmithKline
Tissue Collection Challenges in Co-Development Clinical Trials
Eric Walk, Ph.D., Senior Vice President & CMO, Ventana Medical Systems (invited)
Cancer and Leukemia Group B Pathology Committee Guidelines for Tissue Microarray Construction Representing Multicenter Prospective Clinical Trial Tissues
David Rimm, M.D., Ph.D., Professor, Pathology; Director, Medical Studies; Director, Pathology Tissue Services, Yale University
Don’t Miss the Onsite Tour of LabCorp’s Center for Molecular Biology & Pathology (CMBP) in the Research Triangle Park*
*Included as Part of Your Main Conference Registration
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Biopreservation Protocols Panel
All agree that biopreservation protocols can affect the biomarker (DNA, RNA, protein) of interest; however, there is no protocol consensus. The Biopreservation Protocols Panel provides a forum to determine these effects and provide recommendations on the best protocols to preserve and store these precious biosamples. Join research scientists and managers of biobanks to start this critical dialogue.
Moderator:
Andrew Brooks, Ph.D., COO, RUCDR; Associate Professor, Genetics, Rutgers University
Panelists to be Announced
Case Studies: Biobanker/Biouser Partnerships
This session brings together scientists who use biospecimens for research (“biousers”) with operation managers who collect, process, store, and distribute the biospecimens (“biobankers”). During a co-presentation, biobankers and biousers elaborate on the characteristics of their working partnership as they address the following issues:
- How does the partnership work?
- What are the bottlenecks?
- What does each bring to the table?
- What are the needs?
- Ultimately, what are the scientific results?
Duke-LabCorp Biobanking: Advancing Translational Research through Partnerships
Co-Presenters:
Diane Uzarski, Associate Director, Biobanking Program, Duke Translational Research Institute, Duke University
Hannah O. Maynor, Associate Director, Biorepository, LabCorp Clinical Trials, LabCorp