The Bioprocessing Summit

SC8: Biophysical Characterization in Developing Biopharmaceuticals: The Path to Developability, Stability and Comparability

Thursday, August 21, 2014 | 6:30 - 9:00pm

This interactive dinner course will take a closer look at the biophysical toolbox and approaches for monitoring the higher order structure (HOS) of protein drugs.

The topics to be covered:

  • Assess their physicochemical properties for drug candidate and formulation selection
  • Develop their HOS fingerprint
  • Detect changes in their HOS during development
  • Characterize their variant forms
  • Monitor aggregation

Instructor:

Steven Berkowitz, Ph.D., Consultant; formerly Senior Principal Scientist, Analytical Development, Biogen Idec

Speaker Bios

StevenBerkowitzSteven Berkowitz, Ph.D., Consultant; formerly Senior Principal Scientist, Analytical Development, Biogen Idec

Dr. Berkowitz received his B.S. degree in Biology from Fairleigh Dickinson University and his Ph.D. degree in Biochemistry from New York University. He then spent several years as a post-doctoral fellow at Yale University and the NIH. After his post-doctoral work Dr. Berkowitz held various positions at Celanese Research Company, J.T. Baker, and Lederle Laboratories before taking a position at Biogen Idec where he has spent his last twenty year working in the areas of purification, analytical and formulation development before retiring at the end of 2013.

Dr. Berkowitz’s technical areas of expertise are concentrated in the separation and physical sciences associated with the characterization of a wide range of biopolymers and synthetic polymers.  Much of Dr. Berkowitz’s work has centered on assessing the physicochemical properties, micro-heterogeneity, aggregation properties and higher-order structure of biopharmaceuticals using a range of biochemical and biophysical techniques that has predominately involved the use of light scattering, analytical ultracentrifugation, chromatography, electrophoresis, and various forms of spectroscopy.