Webinar Description:

Antibodies are the most rapidly growing form of therapeutic, with proper methods of biochemical and biophysical characterization being essential as companies and researchers move to develop new candidates. In this webinar, Dr. Shawn Owen (University of Utah) discusses advanced characterization techniques to assess antibody-drug conjugates (ADCs), while Dr. Ellen Lee (Creoptix), goes deep into the biophysical characterization of biologics using the Grating-Coupled Interferometry technology for label-free, real-time affinity and kinetics characterization. These methods can be used for the in-depth analysis of these biologics and for routine product validation.

Learning Objectives:

• Measuring kinetics in biofluids does provide valuable insights into a drug’s efficacy
• How can I best characterize antibody drug conjugates using biochemical and biophysical techniques?
• Determination of level of payload and site of conjugation of ADCs using LC/MS.
• Thermal stability and binding affinity of ADCs characterization using DSC, IR, ITC and GCI.
• What is grating-coupled interferometry technology?

Speakers:

Ellen Lee, PhD
Field Application Specialist
Creoptix AG

With over 10 years of experience in protein research, Dr. Ellen Lee has a deep and solid understanding of molecular biology. Ellen has a PhD from the UT Southwestern Medical Center in Dallas and she has gathered extensive experience as a Field Applications Scientist in the protein quality field, before joining Creoptix in 2019.

Shawn C. Owen, PhD
Assistant Professor, Pharmaceutical Chemistry Department
University of Utah

Dr. Owen is an Assistant Professor in the Pharmaceutical Chemistry department at the University of Utah. He is also an Adjunct Assistant Professor in the Internal Medicine, Biomedical Engineering, and Medicinal Chemistry Departments. His lab utilizes protein engineering and bioconjugation techniques in developing therapeutic and diagnostic platforms to enable precision medicine.