Tuesday April 22, 2014 3:30 - 6:30pm
SC5: Immunology Basics for Chemists
Heba Nowyhed, Ph.D., Postdoctoral Fellow, Laboratory of Catherine Hedrick, Inflammation Biology, La Jolla Institute for Allergy and Immunology
Duygu Sag, Ph.D., Postdoctoral Fellow, Laboratory of Catherine Hedrick, Inflammation Biology, La Jolla Institute for Allergy and Inflammation
Seng-Lai “Thomas” Tan, Ph.D., Head, Cellular and Translational Immunology, EMD Serono Research and Development Institute, Inc.
Review of immune system’s cellular players
- B cells -- life cycle, types, functions
- T cells -- life cycle, types, functions
Review of inflammatory processes
- Cytokine biology
- Receptor pathways
Autoimmune and inflammation-related diseases
- Which are most prevalent? which have the greatest need for new therapies?
- Underlying biologic defects
- Associated targets and their place in signal transduction pathways
Current treatment landscape
- Review of current state of anti-cytokine therapies (mostly biologics)
- Biologics v. small molecules
- What's on the horizon
- What is needed
Heba Natalie Nowyhed, Ph.D., Postdoctoral Fellow, Inflammation Biology, La Jolla Institute.
Dr. Nowyhed received her Ph.D. in Immunobiology from Yale University under the mentorship of Joseph Craft. After completing her graduate work she went on to the La Jolla Institute to work on her postdoctoral fellowship with Dr. Catherine Hedrick in the division of Inflammation Biology. Over the course of her postdoc she has determined the role of a cholesterol transporter in iNKT cells and developed functional experiments to understand T cell receptor interactions and T cell activation against antigen presenting cells. She is currently focused on a novel role for the transcription factor Nur77 in CD8 T cell development and is utilizing mouse models of atherosclerosis, intracellular bacterial infections, and memory cell response to study the function of a subset of CD8 T cells.
Duygu Sag, Ph.D., Postdoctoral Fellow, Inflammation Biology, La Jolla Institute
Dr. Sag received her Ph.D. in Immunology from the University of Louisville School of Medicine under the supervision of Dr. Jill Suttles in 2009. During her Ph.D., she discovered a novel molecular link between metabolism and inflammation. Currently, she is working as a postdoctoral fellow in the laboratory of Dr. Catherine Hedrick at the La Jolla Institute. Her research interest is focused on the impact of intracellular cholesterol homeostasis on immune cells. She discovered novel roles of a cholesterol transporter protein in iNKT cell development and tumor immunity.
Seng-Lai “Thomas” Tan, Ph.D., Head, Cellular and Translational Immunology, EMD Serono
Seng-Lai Tan is a Director and the Head of Cellular and Translational Immunology at EMD Serono Research and Development Institute. He is interested in advancing mechanistic understanding and thus proof of confidence of novel therapeutic agents for the treatment of autoimmune disease. His Team develops cellular assays using primary human cells derived from healthy donors and patient cohorts to help bridge bench-to-bedside and vice versa activities, as well as to enable phenotypic screens to identify novel compounds and drug targets. Prior to joining EMD, Dr. Tan has led cross-functional teams in both large and small molecule drug discovery programs at Eli Lilly and Company, Amgen and Roche.
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