MONDAY, OCTOBER 20
PRE-CONFERENCE SHORT COURSES*
9:00am-12:00pm
(SC1) Imaging Technologies for Target Discovery
Over the last few years it has become evident, that imaging technologies are a very useful tool in drug discovery. This course is designed to provide information on optical and molecular imaging tools and the challenges, opportunities and limits will be discussed. An overview on optical and molecular imaging will be given.
Topics to be covered:
- Overview and Introduction of current imaging technologies
- Strength and limitations of using molecular imaging
- Finding the optimal technology for specific applications
- Imaging with fluorescent proteins
- Live animal imaging
2:00-5:00pm
(SC6) Screening For Potential Drug Targets - Design Strategies for Novel-Generation Kinase Inhibitors
The structural coverage of the human kinome has significantly increased in the last few years. This course will provide useful insights and information on how fragment-based design offers an opportunity for assembling novel inhibitors, monitoring their binding kinetics and improving the residence time. Specific focus on screening technologies such as X-rays will be given.
Topics to be Covered:
- Fragment-Based Inhibitor Assembly
- Monitoring Binding Kinetics
- Aiming at long residence time on target
- Privileged Fragments with cross-target promiscuity within the kinase family fragments with front-loaded bindng kinetics characteristics
Tutors:
Tailor Made Biochemical Assays for Measuring Residence Time
Lars Neumann, Ph.D., Group Leader Assay Development & Screening, Proteros GmbH
X-ray Supported Fragment-Based Design
Gerhard Müller,Ph.D, Chief Scientific Officer, Proteros Fragments, GmbH
Doris Hafenbradl, Ph.D., Executive Vice President, Screening & Proteins, Proteros Biostructures
Frank Leemhuis, Ph.D., Managing Director, MercaChem
*separate registration required
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