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Digital PCR Conference: Technologies and Tools for Precision Diagnostics


Register by July 18 & SAVE up to $400! 

Digital PCR's ability to precisely quantitate, identify mutations, copy number variations, and do gene expression analysis is creating waves across the diagnostics landscape. It is well suited for single-cell analysis and shows promise to become a superior tool in the clinic due to its capacity to work with small amounts of sample. The Third Annual Digital PCR event will bring together industry visionaries and early adopters to discuss digital PCR's capabilities, limitations, and future applications. Researchers will examine applications in cancer biomarker and rare mutation detection, non-invasive fetal DNA analysis, and infectious disease quantification, particularly in HIV. Novel digital PCR devices from startups and academic labs will be showcased. Other topics to be addressed include digital PCR integration with existing technologies, solutions for processing difficult samples as well as increasing sample throughput, and guidelines and best practices for digital detection.

Pre-Conference Short Course: Digital PCR: A Technology Primer

Instructor: Jim Huggett, BSc (Hons), Ph.D., Science Leader, Nucleic Acid Metrology, Molecular & Cell Biology, LGC

This course will introduce the concept of digital PCR (dPCR) and explain how it compares to other molecular methodologies, citing both advantages and disadvantages. Included in the discussion will be the application of dPCR to perform minority target detection, absolute quantification and measurement of copy number variation as well as the analysis of RNA using reverse transcriptase dPCR. The discussion will also include some of the specific challenges associated with performing this technique.

Dinner Short Course: Single-Cell Genomic Analysis

Daniel T. Chiu, Ph.D., A. Bruce Montgomery Professor, Chemistry; Endowed Professor, Analytical Chemistry; Professor, Bioengineering, University of Washington, Seattle
Speaker to be Announced, University of Washington, Seattle

The single-cell sequencing workflow involves complex steps in cell isolation, sample prep, and genomic analysis. This course will introduce attendees to the single-cell sequencing workflow, demonstrating best practices for successful experiment design.


KEYNOTE PRESENTATION

Advancing Diagnostics with Digital Detection: From Quantifying Ultra-Rare Mitochondrial DNA Mutations to Profiling Tumor-Infiltrating Lymphocytes

Jason BielasJason H. Bielas, Ph.D., Associate Member, Translational Research Program, Fred Hutchinson Cancer Research Center (FHCRC); Affiliate Assistant Professorship, Department of Pathology, University of Washington

 

dPCR MEASUREMENT AND ANALYSIS

Guidelines for Minimum Information for Publication of Quantitative Digital PCR Experiments

Stephen Bustin, Ph.D., Professor of Allied Health and Medicine, Anglia Ruskin University

Technical Explanation and Theory of Digital PCR: What Can Go Wrong and Why?

Ross Haynes, Biological Science Technician, Biochemical Science Division, National Institute of Standards and Technology (NIST)

Analysis and Visualization of Digital PCR Experiments – Applications of the dpcR Framework

Stefan Rödiger, Ph.D., Group Leader InnoProfile Group “Image-Based Assays”, Brandenburg University of Technology

A Robust Framework for Digital PCR Data Analysis

Jo Vandesompele, Ph.D., CEO, Biogazelle; Professor, Ghent University


dPCR FOR PATIENT MONITORING AND STRATIFICATION

Using dPCR to Determine Copy Number Variations in order to Select Patients for New Oncology Drugs

Reinhold Pollner, Ph.D., Director, Clinical Trial Assay Development, Genoptix Medical Laboratory, a Novartis Company

Evaluation of EGFR Mutations in Plasma from NSCLC Patients: Utility in Managing Patients on TKI Therapy

Chris Karlovich, Ph.D., Principal Scientist, Molecular Diagnostics, Clovis Oncology

Serial Monitoring of EGFR Mutations in Plasma and Matched Tissue from EGFR Mutant Non-Small Cell Lung Cancer Patients on Erlotinib

Cloud P. Paweletz, Ph.D., Head, Translational Research Laboratory; Biomarker Lead, Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute


MINORITY TARGET DETECTION

Digital PCR for Detecting Rare Genomic Alterations which Enhances Sensitivity in Cell-Free DNA

Rachel Tam, Senior Research Associate, Clinical Assay Development, Oncology Biomarker Development, Genentech, Inc.

Applications of Digital PCR in Oncology: Detecting Residual Disease in Plasma of Early Stage Breast Cancer Patients and Archival Tissue Studies Using Droplet Digital PCR

Rory L. Cochran, Ph.D. Candidate, Ben Ho Park Lab, Graduate Program In Cellular & Molecular Medicine, Johns Hopkins University School of Medicine


COPY NUMBER VARIATION

Development of Configurable Genotyping Assays for Single Color Digital PCR in Cancer

Hanlee P. Ji, M.D., Assistant Professor, Medicine, Division of Oncology, Stanford University School of Medicine

Evaluation of Genetic Stability of HSV Transgenes in a Constructed Vero Cell Line

Ali Azizi, Ph.D., Scientist, Adjunct Professor, Microbiology and Virology, Analytical Research and Development, sanofi pasteur

Sensitive Genetic Assays for Personalized Medicine Using Real-Time and Digital PCR Technologies

Douglas Sanders, Ph.D., Senior Scientist, Novartis


ABSOLUTE QUANTIFICATION

The Application of Digital PCR to Infectious Disease Detection

Jim Huggett, BSc (Hons), Ph.D., Science Leader, Nucleic Acid Metrology, Molecular & Cell Biology, LGC

Diagnostic Use of Digital PCR for Liquid Biopsy

Ekkehard Schütz, M.D., Ph.D., CTO, Senior Vice President, Research, Chronix Biomedical, Inc.

NGS-Assisted DNA-Based Digital PCR for the Detection and Quantification of Residual Disease in CML Patients with Undetectable BCR-ABL1 Transcripts

Mary Alikian, Imperial Molecular Pathology, Imperial Healthcare Trust, Hammersmith Hospital; Centre for Haematology, Faculty of Medicine, Imperial College London

 

For more details on the conference, please contact:
Samantha Lewis
Conference Producer
Cambridge Healthtech Institute
T: (+1) 781-972-5461
E: slewis@healthtech.com 

For exhibit & sponsorship opportunities, please contact:
Jay Mulhern
Manager, Business Development
Cambridge Healthtech Institute
T: (+1) 781-972-1359
E: jmulhern@healthtech.com
 



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