Chemical probes, well-characterized, potent, selective and cell-active modulators of protein function are essential tools in target validation and enable linking of a phenotype to the biology of a specific protein. The wide availability of these high-quality molecules to the research community has enabled new research and accelerated clinical testing. Extensive in vitro selectivity screen is possible only for a limited number of families and should to be complemented by phenotypic profiling, ideally in human model systems, in order to most faithfully provide relevant biomarker and phenotypic read-outs.
- Chemical probes versus drug molecules
- Case studies of chemical probes
- Phenotypic characterisation of chemical probes
Susanne Müller-Knapp, Ph.D.
Chief Operating Officer
SGC Frankfurt, Goethe Universität Frankfurt
Buchmann Institute for Molecular Life Sciences
Susanne Müller-Knapp studied Human Biology in Marburg Germany followed by a PhD in molecular biology at the Karolinska Institute in Stockholm, Sweden (1997). She then had more than 6 years of postdoctoral training in the area of inflammation and gene regulation at the Karolinska Institute and at the DIBIT San Raffaele Scientific Institute in Milan, Italy.
In 2004 Susanne joined the Structural Genomics Consortium, SGC, in Oxford. The SGC is an international public private partnership that currently comprises 9 international pharmaceutical companies and a large network of academic and industrial collaborators. Susanne worked at the SGC first as External Research Manager and then Scientific Coordinator. She has been the Project Manager of the Epigenetic Probe Project, which generates tool compounds with defined specificity and selectivity for epigenetic targets and headed the cell based assay group at the SGC in Oxford testing the cellular activity of the in vitro characterised tool compounds. In her role as COO at the SGC Frankfurt Susanne is now coordinating several probe programs including the global SGC kinase chemical probe program and the donated chemical probe program (DCP).
Cost: No Cost!