We are pleased to announce CHI’s Twelfth Annual High-Content Analysis meeting, the premier event showcasing the latest advancements in HCA applications and technologies. Over the years we have observed the technology mature and its adoption spread into many areas of compound screening/evaluation and functional analysis. The Twelfth Annual High-Content Analysis 2015 meeting will focus on the next steps of technology development, including new assays and probes, more advanced image analysis and data management, high-content screening of 3D models and ultra high-resolution imaging. This year, we will also co-locate CHI’s Inaugural Phenotypic Screening meeting, offering two tracks to choose from, expanded exhibit hall and an offering of user group meetings and dinner courses. The Phenotypic Screening meeting will address the advantages of phenotypic screening vs. target-based screening, and focus on assay development, selection of physiologically-relevant models and subsequent target identification, as well as case studies of phenotypic screens from leading pharma.