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Cambridge Healthtech Institute’s 4th Annual
Higher-Throughput Protein Purification
Supporting Technologies
January 22-23, 2015


High-throughput processes have transformed the traditional protein-by-protein trial-and-error approach for testing criteria and scaling up. This leading meeting on Higher-Throughput Protein Purification investigates HTP in the quest to develop methods that ensure quality and translate to large scale. Automation, robotics and liquid handlers will be discussed, along with developing small-scale models that shed light on bioproduction. Case studies illustrate how leaders in the field are integrating HTP approaches in order to reduce the time and effort needed to successfully establish parameters and achieve pure protein.

Preliminary Agenda


HTP AUTOMATION 

KEYNOTE PRESENTATION

Automated Higher-Throughput Protein Purification Using Enhanced ÄKTA Chromatography Instruments

Kenneth Walker, Ph.D., Scientific Director, Biologics, Amgen, Inc.

Acceleration of Purification Process Development Using High-Throughput Automation

Srinivas Chollangi, Ph.D., Scientist, Bristol-Myers Squibb Co.

Automation of Non-Chromatographic Downstream Processes Gaining on High-Throughput Bioprocess Development

Cornelia Walther, Ph.D., Scientist, Applied Microbiology, University of Natural Resources and Life Sciences Vienna


CONSTRUCTING AND INTEGRATING A HTP PROTEIN PURIFICATION PLATFORM 

Building a High-Throughput Protein Purification Platform

Jiansheng Wu, Ph.D., Senior Scientist, Protein Chemistry, Genentech, Inc.

SEC-TID, a Small Molecule Target ID Platform Utilizing a PDB-Guided Small Molecule-Ligandable Protein Library

Antonin Tutter, Ph.D., Scientific Technical Leader I, Novartis Institutes for BioMedical Research, Inc.

Application of Modular Expression Toolboxes in High-Throughput Protein Expression

Ernst Weber, Ph.D., Lab Head, Protein Engineering and Assays, Bayer HealthCare


HIGH THROUGHPUT TECHNIQUES TO ENSURE QUALITY 

High-Throughput Glycosylation Analysis and Monitoring

Pauline M. Rudd, Ph.D., Professor, Glycobiology, National Institute for Bioprocessing Research and Training (NIBRT)

Using High-Throughput Techniques to Produce Difficult Targets: Flavivirus NS1, a Case Study

William (Clay) Brown, Ph.D., Associate Research Scientist, Life Sciences Institute, University of Michigan


HTP PURIFICATION TO ENABLE DRUG DISCOVERY 

High-Throughput Purification of Antibodies and Antibody Fragments Enabling Biologic Drug Discovery

Benjamin Kemp, Ph.D., Senior R&D Manager, MedImmune, LLC

A High-Throughput-Enabled Pipeline for Eukaryotic Expression and Purification

Ronald D. Seidel, III, Ph.D., Director, Macromolecular Therapeutic Development, and Associate Director, Albert Einstein Protein Production Facility, Biochemistry, Albert Einstein College of Medicine


HIGH-THROUGHPUT TECHNOLOGIES 

Structurally Integrated Biology for the Life Sciences, SIBYLS: High-Throughput SAXS Data Collection

John A. Tainer, Ph.D., Senior Scientist, Lawrence Berkeley National Lab; Director, SIBYLS, Advanced Light Source; Member, Skaggs Institute for Chemical Biology, Professor, The Scripps Research Institute