Morning Short Course

Genetically Engineered Mouse Models versus Patient-Derived Xenograft Models: Comparing Strengths and Limitations 


Monday, February 10, 2014 | 8:30 - 11:30 am | Moscone North Convention Center | San Fransisco, CA 


The versatile agenda for this course aimed at comparative assessment of contemporary approaches to model cancer in two best predictive murine systems will include the following topics:

  • Design, development and preclinical validation of genetically engineered (GEM) and patient-derived xenograft (PDX) mouse models;
  • Review the current spectrum of available GEM and PDX models outlining annotation practices and benefits vs. shortcomings of two different methodologies as highlighted by specific examples;
  • Analyze current and expected impact of modeling cancer in GEMs and PDXs on in-depth disease analysis and designing therapeutic strategies for unmet need” rare cancer types;
  • Discuss informative capabilities of preclinical models to guide decision making at clinical trial steps of oncology drug evaluation;
  • Describe differential approaches in modeling disease evolution vs. advanced/metastatic disease using GEMs and PDXs in the context of multi-facet implications of murine cancer models for e.g. advanced studies on molecular basis of carcinogenesis, biomarker and imaging modality development and preclinical drug efficacy assessment;
  • Provide examples of available integrated GEM and PDX resources, operational workflows and best practices of exploring murine models for translational and preclinical experimentations

Instructors:

Serguei Kozlov, Ph.D., Principal Scientist, Center for Advanced Pre-Clinical Research, SAIC-Frederick, Inc. 

Byron C. Hann, M.D., Ph.D., Associate Researcher, Manager of Pre-Clinical Therapeutics Core, UCSF Helen Diller Family Comprehensive Cancer Center 

 

 



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