PepTalk 2017
PepTalk 2017

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Cambridge Healthtech Institute’s Eighth Annual
Protein Aggregation and Emerging Analytical Tools
Mechanism, Prediction, Screening, Immunogenicity and Formulation Challenges
January 12-13, 2017 | Hilton San Diego Bayfront | San Diego, CA


The popular Protein Aggregation and Emerging Analytical Tools conference covers latest trends, challenges and solutions in understanding, characterization and mitigation of problems generated by protein aggregation. It features in-depth case studies, new and unpublished data and interactive discussions on mechanisms of aggregation, new tools for detection and quantitation of aggregates, and how the data are used in regulatory filings. It also discusses mechanistic understanding of protein aggregation and presents case studies on prevention of particle formation by engineering and formulation approaches, impact of aggregation on production, aggregates as a factor for immunogenicity, and approaches for improvement of biophysical properties of protein solutions.

We invite you to present a poster and attend to join colleagues from around the world in this discussion of the key challenges and solutions in protein aggregation in biotherapeutics.

Preliminary Agenda


UNDERSTANDING AND CONTROLLING ADVERSE PROTEIN AGGREGATION DURING PATIENT HANDLING AND USE


KEYNOTE PRESENTATION: Mishandling of Therapeutic Protein Products by End Users: Particle Formation and Potential Roles in Adverse Immunogenicity

John F. Carpenter, Ph.D., Professor, Pharmaceutical Sciences; Co-Director, Center for Pharmaceutical Biotechnology, University of Colorado Anschutz Medical Center


Towards Particle- and Silicon-Free Protein Drug Products

Gerhard Winter, Ph.D., Professor, Chair, Pharmaceutical Technology and Biopharmaceutics, LMU Munchen


APPROACHES FOR PREVENTION AND CONTROL
OF PROTEIN AGGREGATION

Understanding and Overcoming Tradeoffs between Antibody Affinity, Specificity and Stability

Peter Tessier, Ph.D., Chemical & Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute

Talk Title to be Announced

Thomas Laue, Ph.D., Professor, Biochemistry and Molecular Biology; Director, Biomolecular Interaction Technologies Center (BITC), University of New Hampshire


RAPID TOOLS FOR PREDICTION, MEASUREMENT
OF AGGREGATION, VISCOSITY AND STABILITY

A Rapid Real-Time Biosensor to Detect Preaggregates and Screen Formulations of Therapeutic Proteins

Subhashchandra Naik, Ph.D., Postdoctoral Researcher, Chemical and Biomolecular Engineering, University of Delaware

Integrating Novel Tools into Development Workflow of Biologics: nanoDSF and MST for Discovery, Development and QC

Alexey Rak, Ph.D., Director, Bio Structure & Biophysics, Sanofi R&D, France

Impact of Interfacial Interactions on the Formation of Particles, Aggregation of Proteins, and Their Prevention: Role of Surface Energetics and Their Application to Container Compatibility and Protein Purification

Jinjiang Li, Ph.D., Senior Principal Scientist, Drug Product Science & Technology, Bristol-Myers Squibb Co.

Optimizing Protein Stability through Integration of Cutting-Edge Analytical Tools with Rational, Molecule-Specific Approach to Process and Formulation Development

Danny K. Chou, Pharm.D., Ph.D., President and Founder, Compassion BioSolution; Former Senior Research Scientist, Biologics Development, Gilead Sciences




For questions about the meeting, please contact:

Nandini Kashyap
Conference Director
Cambridge Healthtech Institute
Phone: 781-972-5406
Email: nkashyap@healthtech.com

For partnering & sponsorship information, please contact:

Companies A-K
Jason Gerardi
Manager, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5452
Fax: 781-972-5470
Email: jgerardi@healthtech.com

Companies L-Z
Carol Dinerstein
Director, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5471
Fax: 781-972-5470
Email: dinerstein@healthtech.com