January 13 - 17, 2014
Renaissance Hotel and Palm Springs Convention Center Palm Springs, California

A Community Dedicated to the
Evolving Field and Future of Biotherapeutics
2014 Archived Content

SHORT COURSE 14: CHALLENGES OF MULTI-COLUMN CONTINUOUS CHROMATOGRAPHY IN DOWNSTREAM PROCESSING 

 

Tuesday, January 14 | 5:00-8:00 pm


Chromatographic processes are important in the downstream processing of biomolecules. Over the past 10 years, a significant shift in the downstream approach has taken place, especially after the tremendous increase in the upstream expression levels of monoclonal antibodies. MCC chromatography in sequential and countercurrent mode has become an attractive tool to overcome the “bottleneck.” Although the SMB technology has a proven record in the manufacture of synthetic pharmaceuticals, barriers still remain to implement the technology into the biopharmaceutical industry.

The topics to be covered:

  • Introduction to process and multi-column continuous chromatography
  • Fundamental background for the design of these processes
  • Technical specifications of the process chromatographic equipment
  • Obstacles of implementing these processes into the downstream processing
  • Applications and current developments

 

Instructor:

Dr.-Ing. Kathleen Mihlbachler, Independent Consultant

Speaker Biographies

Dr.-Ing. Kathleen Mihlbachler, Independent Consultant 

Kathleen MihlbachlerDr. Mihlbachler has worked in the field of process chromatography for more than 15 years. As a Sr. Researcher at BMS, Eli Lilly and Pfizer, she involved in the development, scale-up and manufacturing of purification/separation processes for chiral and non-chiral compounds, peptides and proteins, in particular to implement continuous processes. Since 2012 Dr. Mihlbachler is an external consultant for LEWA-NIKKISO where she has supported the technical transfer of process chromatographic technology and consulted in customer projects. From 2011 to 2013, Dr. Mihlbachler has taught undergraduate courses for chemical and biomedical students in the Department of Chemical, Biological and Pharmaceutical Engineering at New Jersey Institute of Technology.

Dr. Mihlbachler has been the AIChE Programming Chair of the Area 2G BioSeparations from 2011 to 2013. Since 2007 she is also a member of the Scientific Committee of the International Symposium on Preparative Chromatography, since 2010 she chaired the Poster Award Committee and since 2010 she co-instructed workshops on ”Preparative chromatography of pharmaceutical intermediate and API” at this annual symposium.

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Training Seminars 

Mon-Tues, January 13-14 

Biologics Formulation and Delivery  

 


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