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SHORT COURSE 2: THE S-SCORE SYSTEM: A TOOL FOR IDENTIFYING
NEW CANCER TARGETS FOR ANTIBODY-DRUG THERAPY

  Sunday, January 18 | 5:00-8:00 pm 

The course will discuss a new method that allows for the identification and prioritization of predicted cancer genes for future analysis. This method generates a gene-specific score called the “S-Score” by incorporating data from different types of analysis including mutation screening, methylation status, copy-number variation and expression profiling. I will show some results where method was applied to the data from The Cancer Genome Atlas and allowed the identification of known and potentially new oncogenes and tumor suppressors associated with different clinical features including shortest term of survival in ovarian cancer patients and hormonal subtypes in breast cancer patients. I will also show a web server that provides access to the S-score algorithm and allows users to query the system with clinically relevant issues. Moreover, I will present case studies in which the S-score has been used to identify targets for antibody-based therapy.


Instructor:

Sandro J. de Souza, Ph.D., Laboratory of Computational Biology; Ludwig Institute for Cancer Research


 

Speaker Biography:   

 

Sandro J. de Souza, Ph.D., Laboratory of Computational Biology; Ludwig Institute for Cancer Research

Sandro J. de SouzaSandro J. de Souza is a biologist with a Ph.D in Biochemistry from the University of São Paulo, Brazil. From 1995 to 1998, he was a Pew Latin American Fellow at Harvard University working with Nobel laureate Wally Gilbert. He returned to Brazil to become one of the leaders of the genomics initiative in the country as a associated member of Ludwig Institute or Cancer Research (from 1999 to 2012). Now, he is a Professor of Bioinformatics at the Brain Institute-UFRN, in Natal, Brazil and president of the Institute of Bioinformatics and Biotechnology. Other awards include: TR100 by MIT's Technology Review in 1999, Young Global Leader by the World Economic Forum in 2009 and a Tinker Visiting Professor at University of Chicago in 2011.



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