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Cambridge Healthtech Institute’s 17th Annual
Recombinant Protein Expression and Production
Achieving Quality and Quantity
January 21-22, 2015


Biopharmaceuticals currently represent the fastest-growing sector of the pharmaceutical industry, driven by a rapid expansion in the manufacture of recombinant protein-based drugs. To meet the demand, it is crucial to increase the throughput of expression, production and purification processes and systems.

Cambridge Healthtech Institute’s Recombinant Protein Expression and Production conference explores the newest data and innovations relating to the best choices in hosts/systems, as well as ways to revive existing systems and make them work more effectively to produce the quality and quantity of the desired biotherapeutic.

Preliminary Agenda 


EXPRESSION: IMPROVING YIELDS

Effect of Ambient Light on Monoclonal Antibody Product Quality during Small-Scale Mammalian Cell Culture Process in Clear Glass Bioreactors

Mary Mallaney, Engineer I, Purification Development, Genentech, Inc.

Optimizing the Cell Line Development Workflow to Support Accelerated Timelines

Christine DeMaria, Ph.D., Associate Director, Therapeutic Protein Expression, Global Biotherapeutics Development, Sanofi US

The Rapid Generation of Multiple Antibody Toxin Conjugates: Expression in Eukaryotic Algae

Miller Tran, Ph.D., Senior Scientist, Lead Discovery, Verdant Therapeutics, Inc. 

Taking Protein Production in Escherichia coli to the Next Level

David Vikström, Ph.D., CTO, Xbrane Bioscience

 

 


MEMBRANE PROTEINS: EXPRESSION AND PRODUCTION

Designer Surfactant-Like Self-Assembling Peptides for Membrane Protein Purification and Stabilization

Sotirios Koutsopoulos, Ph.D., Research Scientist, Center for Biomedical Engineering, Massachusetts Institute of Technology

Production of Human Integral Membrane Proteins in Mammalian Cells

James D. Love, Ph.D., Director, Technology Development, Biochemistry, Albert Einstein College of Medicine 

Advances for Maximizing Protein Yields in HEK293 and CHO Transient Expression

Henry C. Chiou, Ph.D., Associate Director, Life Science Solutions, Thermo Fisher Scientific

 
 

CHO CELL LINE ENGINEERING AND DEVELOPMENT

Omics-Guided Cell Line Engineering: Reducing High Mannose by Overexpressing N-Glycosylation Pathway Regulators

Shivani Gupta, Ph.D., Associate Scientist, Cell Line Development, Amgen, Inc.

Mammalian Systems and Synthetic Biotechnology for Recombinant Protein Production

Dong-Yup Lee, Ph.D., Assistant Professor, Chemical and Biomolecular Engineering, National University of Singapore; Senior Research Scientist, Bioprocessing Technology Institute, A*STAR

Improving CHO Cell Factories Using Systems Biology and Genome Editing Technologies

Helene Faustrup Kildegaard, Ph.D., Co-Principal Investigator, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark

Increasing Monoclonal Antibody Production Using Low-Intensity Pulsed Ultrasound

Jie Chen, Ph.D., Professor, Electrical and Computer Engineering, University of Alberta, Edmonton