PepTalk 2017
PepTalk 2017

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Cambridge Healthtech Institute’s Nineteenth Annual
Recombinant Protein Expression and Production
Achieving Quality and Quantity
January 10-11, 2017 | Hilton San Diego Bayfront | San Diego, CA


Biopharmaceuticals currently represent the fastest-growing sector of the pharmaceutical industry, driven by a rapid expansion in the manufacture of recombinant protein-based drugs. Consequently, the efficient expression and production of these valuable biomolecules face challenges in improving their quantity and quality while minimizing time and cost. To meet these demands, an increasing variety of recombinant production platforms are being developed. Unfortunately, there is no “universal” production system which can guarantee high yields of recombinant protein, particularly as every biomolecule itself causes its own issues in terms of expression. To meet the demand, it is crucial to increase the throughput of expression, production and purification processes and systems.

Cambridge Healthtech Institute’s Recombinant Protein Expression and Production conference explores the newest data and innovations relating to the best choices in hosts/systems, as well as ways to “rescue” existing systems and make them work more effectively to produce the quality and quantity of the desired biotherapeutic.


EXPRESSION AND PRODUCTION OF:

Unique Proteins
Optides: A Novel Mid-Size Medicine Drug Discovery Platform Based on Knotted Proteins
Ashok D. Bandaranayake, Ph.D., Director, Bioprocess Development, Peptide Drug Discovery Initiative, Fred Hutchinson Cancer Research Center

Membrane Proteins
Strategies for Optimizing GPCR Expression and Production: Multi-Milligram Quantities of Functional Cannabinoid Receptor Isolated by Tandem Affinity Chromatography
Alexei Yeliseev, Ph.D., Staff Scientist, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH

Production of Chemokine/Chemokine Receptor Complexes for Structural Studies

Martin Gustavsson, Ph.D., Staff Scientist, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego


Antibodies
Optimizing Antibody Expression by Using Natural Framework Diversity and Host Engineering in a Live Bacterial Antibody Display System
Noelle Lombana, Ph.D., Senior Scientific Researcher, Antibody Engineering, Genentech

Rapid Production of Biologics with Pichia pastoris

Kerry Routenberg Love, Ph.D., Research Associate & Technical Program Manager, InSCyT Program, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology


CELL-FREE SYSTEMS

A Cell-Free Expression and Purification Platform for Rapid and Flexible Production of Protein Biologics

John Dresios, Ph.D., Chief Scientist and Technical Fellow, Leidos, Inc.


CHO CELLS: ENGINEERING HIGH(ER) PRODUCERS

A Predictable, Plug-and-Play Cell Culture Platform Process

James Lambropoulos, Engineer III, Cell Culture Development, Biogen

In the Pursuit of High Producers: Use of the Sony SH800 Cell Sorter for the Selection of Cell Lines with Superior Productivity Characteristics

Nadia Amharref, Ph.D., Scientist, Cell Line Development, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH

Engineering Protein Production Hosts

Bjørn Voldborg, MSc, Director, CHO Cell Line Development, The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark




For questions about the meeting, please contact:

Mary Ann Brown
Executive Director, Conferences
Cambridge Healthtech Institute
Phone: 781-972-5497
Email: mabrown@healthtech.com

For partnering & sponsorship information, please contact:

Companies A-K
Jason Gerardi
Manager, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5452
Fax: 781-972-5470
Email: jgerardi@healthtech.com

Companies L-Z
Carol Dinerstein
Director, Business Development
Cambridge Healthtech Institute
Phone: 781-972-5471
Fax: 781-972-5470
Email: dinerstein@healthtech.com