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2013 NGX: Applying Next-Generation Sequencing

This summer experienced researchers from large sequencing centers, core laboratories and specialized groups will convene to share their practical knowledge, real-world experiences and solutions at CHI's "NGx: Applying Next-Generation Sequencing" event.

In addition to the flagship Sequencing Strategies for Success and Sequencing Data Analysis conferences, this year's event features two new programs: Dynamics of the Microbiome on Health and Disease focusing on understanding the role of the microbiome to offer new insights into disease processes and discovery of new therapeutic strategies, and Single-Cell Sequencing showcasing the links between cell variation in tissues and organ function and further elucidating the origins of diseases.

» Sequencing Strategies for Success 

» Dynamics of the Microbiome on Health and Disease 

» Sequencing Data Analysis and Interpretation 

» Single-Cell Sequencing 

» Plenary Keynote Session


Jeffery SchlossJeffery A. Schloss, Ph.D., Director, Division of Genome Sciences, National Human Genome Research Institute, National Institutes of Health - Biography 

The initial sequencing of the human genome spurred an appetite for much more human sequence information to better understand the contributions of human sequence variation to health and disease. However, despite dramatic reductions during the Human Genome Project, the cost of sequencing was clearly too high to collect the very large numbers of human and numerous other organism genome sequences needed to achieve that understanding. In 2004, NHGRI launched parallel programs to reduce the cost of sequencing a mammalian genome initially by two (in five years), and eventually by four orders of magnitude (in ten years). This presentation will summarize the technologies that are in high-throughput use to produce stunning amounts of sequence and related data and novel biological insights, and will emphasize technologies currently emerging and on the horizon that may provide human genome sequence data with the nature, quality, cost and turnaround time needed for applications in research and medicine.

David-GalasDavid Galas, Ph.D., Principal Scientist, Pacific Northwest Diabetes Research Institute - Biography 

The discovery of foreign RNA in blood and tissues of humans and mice raises many questions, including its origins, the mechanisms of its transport and stability and what, if any, functions it has. I will discuss what we know about circulating exRNA in human plasma and the use of NGS in the exploration of this new area of investigation in biology and medicine.

Sherman-WeissmanSherman Weissman, Ph.D., Sterling Professor of Genetics and Medicine, Yale University School of Medicine - Biography 

Studies of single cells are being approached by widely different methods, principally either florescence microscopy including super-high resolution methods, cloning and expansion of single cells or most generally applicable, genomic-scale nucleic acid analyses. The last includes single-cell DNA sequence analysis, gene expression analysis and most recently analyses of telomere length, DNA methylation and potentially closed regions of chromatin. Also, in the near future, it may be possible to combine several analyses of a single cell, including mRNA expression, genomic DNA methylation and protein secretion. These approaches will have major value for diverse fields, including molecular analysis of the early stages of development, the nature and heterogeneity of stem cells and transient repopulating cells in various systems including the hematopoietic system, the nature and extent of heterogeneity of neurons, heterogeneity in neoplasia and in functional subsets of cells of the immune system. A substantial experimental challenge is to distinguish technical variation from stochastic and deterministic events in single cells. Another, broader challenge is to correlate the results of genomic properties that necessarily involve destruction of the cell with the functional properties and potential of the individual cell being analyzed. These issues will be discussed briefly in the presentation.

Yaniv-ErlichYaniv Erlich, Ph.D., Principal Investigator, Whitehead Fellow, Whitehead Institute for Biomedical Research - Biography 

Sharing sequencing datasets without identifiers has become a common practice in genomics. We developed a technique that uses entirely free, publicly accessible Internet resources to fully identify individuals in these studies. I will present quantitative analysis about the probability of identifying U.S. individuals by this technique. In addition, I will demonstrate the power of our approach by tracing back the identities of multiple whole-genome datasets in public sequencing repositories.

PodcastGenetic Privacy: Technology and Ethics with Yaniv Erlich 


View onsite coverage from last year's event to hear testimonials, interviews and what thought leaders are saying about the use of NGS over the past years and where it will take us in the future. 



For more details on the conference, please contact: 

Mary Ann Brown
Executive Director, Conferences
Cambridge Healthtech Institute
250 First Avenue, Suite 300
Needham, MA 02494
T: 781-972-5497
E: mabrown@healthtech.com 

For exhibit and sponsorship opportunities, please contact: 

Jay Mulhern
Manager, Business Development, Conferences & Media
Cambridge Healthtech Institute
250 First Avenue, Suite 300
Needham, MA 02494
T: 781-972-1359
E: jmulhern@healthtech.com 

Download Conference & Course Catalog

CHI Catalog March 2018 - August 2018 Cover