June 27, 2017 | 11 am to 12 pm EDT

Sponsored by

Webinar Description:

The KBI Biopharma formulation development platform utilizes high-throughput biophysical analysis, in the early stages, to reduce the formulation design space to a feasible zone. In the later stages, the optimal formulations are exhaustively assessed for their efficacy before selecting a final formulation. Unit and Hunk analyses are used, respectively, in the early and later stages of formulation development. Unit analysis is high throughput and the data is easily interpretable. Hunk analysis is more detailed and time consuming, but can offer insightful predictions about long term stability when the data is generated and analyzed properly.

Learning Objectives:

• Learn how thermal stability ranking can be accelerated by higher throughput instrumentation
• See how additional quantitative information can be generated by chemical denaturation
• Learn how complementary quantitative data can provide a larger picture on biologic stability

Speaker Information:

Andrew Hagarman

Senior Scientist

KBI

I grew up in the Philadelphia area and attended Drexel University for my undergrad and graduate degrees. I graduated from Drexel University in 2010 with a PhD in Chemistry from the lab of Reinhard Schweitzer-Stenner with a concentration in Protein Biophysics. My thesis focused on conformational propensities of amino acid residues and native/non-native structural states of Cytochrome c. After graduating I was a Postdoctoral Associate for 2+ years in the Biochemistry department at Duke University in the lab of Terry Oas. In the Oas lab I mainly worked on folding thermodynamics and kinetics of a multidomain protein, Staphylococcal protein A. In 2012 I began working for KBI Biopharma, Inc. in Durham, NC. I started working there as a scientist and now I manage a group of 6 analysts within the Biopharmaceutical Development department.

Joe Barco

Director, Product Marketing

Unchained Labs

Joe Barco is the Director of Product Marketing at Unchained Labs. He is responsible for new product launches and product development for protein analytical tools. Joe received his PhD in Chemistry from Stanford University. He has spent 15 years in the biotechnology instrumentation arena, first as an applications scientist, followed by positions of increasing responsibility in product management and marketing. His main interest is bringing better tools to scientific discovery.