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Hit the Stability Jackpot with Hunky: Quantify Protein Stability and Assess Aggregation Risks



February 28, 2018
11 am to 12 pm ET

 

Sponsored by

Preview:

 

Webinar Description:

Many methods for studying protein stability and aggregation are qualitative, which can cause uncertainty when moving drug candidates and formulations forward. In contrast, Hunky gives you the ΔG of a protein which is a powerful and quantitative indicator of the amount of unfolded protein present in a sample at ambient temperatures. Moreover, inherent in the ΔG values is information about the likelihood and pathway of aggregation of the protein.

In this webinar, Dr. Greg Manley will discuss the benefits of making routine ΔG measurements with Hunky as part of the process of developing biologics and optimizing formulations. This quantitative data can be used in conjunction with orthogonal and more traditional thermal melting (Tm) measurements to reduce risk when developing biologics.

  • See how ΔG provides more quantitative information on protein stability than other stability measurements.
  • See how ΔG can give insights into protein aggregation.
  • Learn how Hunky makes it easy to implement these measurements as part of your routine process.

Speaker:


Greg Manley, Ph.D.

Sr. Applications Scientist

Unchained Labs

Greg Manley is a Sr. Applications Scientist at Unchained Labs. Greg graduated with a PhD in Biophysical Chemistry from Yale University. He has worked on developing and supporting analytics and automated workflows to improve biologics development as a part of Freeslate and Unchained Labs.



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