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High-throughput Analytics for Formulation and Process Development of Bio- and Nano-therapeutics






April 12, 2017
11 am to 12 pm EDT

 

Sponsored by
Wyatt Tech

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Webinar Description:

Timely, effective development of therapeutic proteins and nanoparticles requires comprehensive analytics across a variety of conditions, excipients, and candidate molecules.

A versatile and powerful method for obtaining these analytics is high-throughput dynamic light scattering (HT-DLS), performed in low-volume microwell plates. While DLS is widely used to characterize size and aggregation of particles from nanometers to microns, HT-DLS extends those measurements to cover a diverse array of screening techniques designed to weed out low-performing formulations prior to costly stability studies.

This webinar will cover the use of HT-DLS in evaluating size, aggregation, colloidal stability, and conformational stability of proteins and nanoparticles in the context of screening formulation and process development conditions.

Learning Objectives:

  • How HT-DLS turns standard, labor-intensive DLS into a fast, automated solution for screening a large panel of conditions and/or candidate therapeutics
  • How HT-DLS contributes to biophysical research on the self-assembly and biological interactions of therapeutic nanoparticles
  • How HT-DLS contributes to rapid product development, assessing colloidal stability and conformational stability to optimize the selection of candidate molecules and pre-formulation conditions
  • How HT-DLS contributes to rapid process development, evaluating a matrix of process conditions to optimize parameters such as time, temperature and excipients

Speakers:

Daniel SomeDaniel Some, Ph.D.

Principal Scientist

Wyatt Technology Corp.


Daniel Some is Principal Scientist at Wyatt Technology Corp. He has been with Wyatt for over twelve years, first in R&D and then in the marketing department. Prior to joining the scientific instrumentation world his professional endeavors included the semiconductor and defense industries. Dr. Some completed his undergraduate degree in physics at the Technion Israel Institute of technology, his doctoral research in the Brown University physics department, and postdoctoral research at Los Alamos National Lab and the Weizmann Institute of Science.



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