Applications of Detection Theory in Diagnostics

March 3, 2011
11:30 a.m. - 1:00 p.m. EST



John C. Carrano, PhD.,  President, Carrano Consulting, LLC

Course Description:
The fundamental goal of this course is to enable you to assess and explain the performance a diagnostic platform, or any other type of system that is attempting to give, with some level of confidence, a determination of the presence or absence of a “target.” In this case the term “target” may be a wide variety of types (e.g. a biological pathogen, or an analyte, etc.).  We will rigorously cover the theory and mathematics underlying the construction of the “Receiver Operating Characteristic (ROC)” curve, including dichotomous test histograms, false positives, false negatives, sensitivity, specificity, and total accuracy. 

Learning Objectives:

  • Define false positives, false negatives and dichotomous test.
  • Define sensitivity, specificity, limit-of-detection, and response time.
  • Understand and analyze a dose-response curve.
  • Construct and analyze a Receiver Operating Characteristic (ROC) curve from raw data.
  • Define Positive Predictive Value (PPV) and Negative Predictive Value (NPV).
  • Interpret detector performance trade-offs using a ROC curve.


Who Should Attend:
This course is designed for scientists, engineers, and researchers that are involved in sensor design and development, particular from the standpoint of complex data analysis.  Application areas for which Detection Theory is most relevant includes biological detection, medical diagnostics, radar, multi-spectral imaging, explosives detection and chemical agent detection.

Instructor Biography:
John CarranoJohn Carrano is President of Carrano Consulting, LLC.  Previously, he was the Vice President, Research & Development, Corporate Executive Officer, and Chairman of the Scientific Advisory Board for Luminex Corporation, where he led the successful development of several major new products from early conception to market release and FDA clearance. Before joining Luminex, Dr. Carrano was as a Program Manager at DARPA, where he created and led several major programs related to bio/chem sensing, hyperspectral imaging and laser systems.  Dr. Carrano is a West Point graduate, and holds a doctorate in Electrical Engineering from the University of Texas at Austin.  He has co-authored over 60 scholarly publications and has 3 patents pending. He is an SPIE Fellow.

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