October 1, 2014
11:00 am to 12:00 pm EDT

Sponsored by
Solvias AG

Webinar Description:

The aim of a crystallization process is to produce the optimal solid form with all desired properties such as particle size, particle shape, bulk density, purity, yield, residual solvent content etc. In order to reach this goal many steps need to precede the crystallization development. The seminar will describe the steps involved in achieving an optimized crystallization process.

Learning Objectives:

  • Identifying and characterizing the optimal salt or co-crystal In a salt and/or co-crystal screening process.
  • Conducting an effective polymorph or solvate screening to identify all relevant forms, characterizing and determining their thermodynamic relationships.
  • Selecting the optimal form, developing a small scale crystallization process, optimizing purity, yield, speed, and particle size distribution.
  • Scaling up the process in a kilo-lab, followed by production on a kg-scale in a GMP-facility.
  • Assuring accurate and rapid communication and efficient know-how transfer.


Rolf HilfikerRolf Hilfiker, PhD
Vice President, Head of Solid State Development
Solvias AG

Rolf Hilfiker is Head of the Department Solid-State Development at Solvias AG. Solvias AG is a scientific services company focused on leveraging expertise in various scientific disciplines to accelerate the drug discovery and development process. The department of some 20 people does contract research and development in the solid-state area (i.e. polymorphism studies, salt and co-crystal screening and selection, method development, crystallization optimization, etc.).

Rolf obtained his Ph.D in physical chemistry at the University of Basel, Switzerland. From 1987-89 he was Post Doc at SUNY, New York and from 1989-1992 Senior Research Fellow at the University of Basel. He has more than twenty years of experience in an industrial R&D environment at Ciba-Geigy, Novartis, and Solvias. Under his guidance, Solvias became one of the leading solid-state service providers in the world. He is author of more than 60 scientific publications as well as numerous patents in various areas of physical chemistry and editor of “Polymorphism – In the Pharmaceutical Industry”, Wiley-VCH, 2006.

Cost: No cost!