Polysorbates 20 and 80 are excipients used in >70% of marketed parenteral biological drugs to improve product stability and shelf life. However, when formulations containing these excipients are stored for long periods of time at low temperatures, visible and subvisible particles are formed. There exists a need to distinguish degraded polysorbate from other particle types but high-throughput, sensitive, and specific analysis of polysorbate particles has been difficult due to their complex chemistry, their low concentrations, and the fact that they appear like other particle types when using optical imaging techniques.
Halo Labs has solved this perennial needle in a haystack problem. Using the Aura™ polysorbate can be quickly identified and distinguished from other particle types. Using the Aura’s high throughput, low volume format, months of development time can be saved by knowing the source of particles in your formulation and distinguishing aggregated drug product from degraded excipients.
- Learn new techniques to reduce stability optimization and development time.
Bernardo Cordovez, PhD
CSO and Founder,
Bernardo leads application development at Halo Labs. Prior to founding Halo Labs, Bernardo was a Postdoctoral Associate at Cornell University, where he also obtained his M.S. and Ph.D. degrees in Mechanical Engineering. His wide range of technical experience includes particle analysis, detection and manipulation, drug delivery devices, microfluidics, nanophotonics and bioenergy production.
Cost: No Cost!