This 60-minute webinar provides an overarching review of and instruction in the theory behind protein footprinting techniques and applications. Receive instruction in the various benchtop covalent modification approaches as well as rapid labeling techniques such as X-ray synchrotron and Fast Photo-Oxidation of Protein (FPOP) hydroxyl radical protein foot-printing (HRPF). Examine the practical implications to applied research in biopharmaceutical research, protein interaction, biosimilar development, epitope mapping, paratope mapping, ligand-binding, drug-protein interaction, and conformational change analysis.
Mark R. Chance, PhD
NeoProteomics, Inc. Co-Founder & CSO
Vice Dean for Research at Case Western Reserve University, School of Medicine
Dr. Chance is an internationally recognized expert in proteomics and structural biology who has built multiple internationally recognized science and training programs over a 30-year career in academia. He has published over 290 papers with over 14,000 citations with an H-index of 69 (Google scholar). He is currently Vice Dean for Research and holds the title of Distinguished University Professor and Professor appointments in the Departments of Nutrition, Genetics & Genome Sciences, and General Medical Sciences at the School of Medicine of Case Western Reserve University (CWRU). At CWRU, he directs the Center for Proteomics and Bioinformatics, the Center for Synchrotron Biosciences, and the Systems Biology Graduate Program. He is also holder of the Charles W. and Iona A. Mathias Chair in Cancer Research.
Joshua S. Sharp, PhD
GenNext Technologies, Inc. CTO; Assoc. Professor of Pharmacology
Assoc. Professor of Chemistry and Biochemistry at the University of Mississippi
Dr. Sharp is an internationally recognized expert in hydroxyl radical protein footprinting and biological mass spectrometry. He has numerous articles in protein footprinting spanning over 18 years of work. In addition to serving as Chief Technology Officer of GenNext Technologies, Inc., Dr. Sharp holds Associate Professor appointments in the Department of BioMolecular Science and the Department of Chemistry and Biochemistry, as well as a Research Professor appointment at the Research Institute of Pharmaceutical Sciences at the University of Mississippi. Dr. Sharp is Director of the Glycoscience Center of Research Excellence, an NIH Center of Biomedical Research Excellence.