The purification requirements in the biopharmaceutical industry will be even more demanding in the coming years due to increased awareness of product-related impurities like oligomers, variants, positional isomers, and glycoforms. These impurities need to be separated from the final product. Dr. Raja Ghosh’s work focuses on the design and development of efficient chromatography devices that combine high-speed with high-resolution in separation. He speaks with Dr. David Wood of the Ohio State University about how the chromatography devices he is developing address these challenges.

BIOs

Raja Ghosh, PhD, Professor & Research Chair, Chemical Engineering, McMaster University
Raja Ghosh obtained his doctorate degree in Engineering Science from Oxford University, United Kingdom. He is currently Professor of Chemical Engineering at McMaster University, Canada. His research interests are primarily in the areas of equipment design and process development for membrane and chromatographic separations. Application areas that interest him include purification and analysis of protein biopharmaceuticals, membrane bioreactors for mammalian cell culture, and water treatment. He has authored two books, Protein Bioseparation Using Ultrafiltration and Principles of Bioseparations Engineering, and has published over 130 research papers. His awards and accolades include a Commonwealth Scholarship and a Canada Research Chair position.

David W. Wood, PhD, Professor, Chemical & Biomolecular Engineering, The Ohio State University
David Wood is currently a professor of Chemical and Biomolecular Engineering at The Ohio State University, where he continues to work on self-cleaving tag technologies for research and biopharmaceutical applications.  He holds an undergraduate degree from Caltech with a double major in biology and chemical engineering, as well as a PhD from Rensselaer Polytechnic Institute in Chemical Engineering and has experience in downstream processing and process development at Amgen and Bristol Myers Squibb.  He has published over 50 papers, book chapters and reviews in protein engineering, and holds several patents on technologies developed in his lab.  Most recently, he is a co-founder of Protein Capture Science; a company formed to commercialize his split-intein technology for protein purification.