Explore AAV formulation and stability with Big Tuna and Uncle
November 11, 2020
11 am to 12 pm EST

Webinar Description:

Adeno-associated virus (AAV) formulation selection and stability characterization is an underexplored space due to low assay throughput and high sample volume requirements. To push the frontier in these areas, we started with Big Tuna’s ability to concentrate and buffer exchange many AAV samples in parallel and into multiple formulations. A suite of formulation conditions was then tested using Uncle’s new application for studying AAV stability and aggregation. Combining automated buffer exchange and AAV stability measurements in high throughput and on a small scale makes Big Tuna and Uncle the perfect guides for mapping out the AAV formulation space.

Learning Objectives:

  • Learn to assess AAV stability based on genome release, capsid stability, and aggregation
  • See how to automate buffer exchange and add degrees of process control that are not possible with manual approaches
  • Create strategies to do more analytical measurements with less sample when the right tools are available


Donna Chen
Product Manager
Unchained Labs

Donna Chen is a product manager for Biologics Workflows at Unchained Labs. She graduated with Bachelor of Science degree in genetics from the University of California, Davis and a Master’s degree in computer and information systems from the University of Boston. Donna has more than 16 years of experience working in areas of novel proteomics platform development, therapeutic protein drug discovery, LIMS implementation, and lab automation.

Ross Walton, PhD
Applications Scientist Analytics
Unchained Labs

Ross Walton is an Application Scientist for Analytics at Unchained Labs. He has published works on single-particle protein analysis by transmission electron microscopy and the interaction of the innate immune system and viruses in cancer. He did his undergraduate work at UC Berkeley and earned his PhD in Molecular Genetics and Microbiology from Duke University.

Cost: No Cost!