Feb. 4, 2015
Time: 11:00AM EST/8:00AM PST
Length: 60 min.

Wyatt Tech

In this webinar we present a comprehensive suite of analytical techniques based on light scattering. These essential R&D tools are vital to the biophysical characterization of macromolecules such as proteins and polymers, as well as VLPs, viruses and other nanoparticles that constitute modern vaccines.

Case studies will show how multi-angle light scattering (MALS) and dynamic light scattering (DLS) instrumentation - whether in standalone mode or in combination with a separation system, such as SEC or FFF – solve key analytical challenges in vaccine development, formulation and quality control.

Learning Objectives:

  • Determination of molar mass, size and composition for biopolymers and protein-polysaccharide conjugate vaccines, by SEC-MALS
  • High-resolution characterization of size, conformation and composition of virus, VLP, liposome, and emulsion nanoparticles, by FFF-MALS
  • High-throughput vaccine formulation and stability studies, by plate-based DLS
  • Label-free, immobilization-free analysis of antigen-antibody and more complex biomolecular interactions, by CG-MALS


      Who Should Attend:

      • R&D managers who encounter common challenges associated with biophysical characterization.
      • Researchers interesting in learning about new analytical techniques applicable to vaccine research and development.
      • Project Supervisors needing more information about cutting-edge technology for biopolymer and nanoparticle characterization.

              Michelle Chen, Ph.D., Head of Analytical Services, Wyatt Technology Corporation Dr. Chen is the Director of Analytical Services at Wyatt Technology Corp., overseeing new application development, sample analysis services at Wyatt’s Application Lab, technical sales support and instrument quality control. She graduated from the Chemical Engineering Department of Yale University, where her doctoral work focused on the development of novel approaches for high-speed and high-efficiency liquid chromatography of biopolymers.

              Since joining Wyatt Technology in 1996, Dr. Chen has relentlessly pursued new ways of characterizing synthetic and biological polymers by incorporating multi-angle light scattering and dynamic light scattering detection with HPLC and field flow fractionation.